Therapy Detail
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| Therapy Name | Imetelstat |
| Synonyms | |
| Therapy Description |
Imetelstat (GRN 163L) inhibits telomerase activity, resulting in telomere shortening and potentially leading to increased tumor cell death (PMID: 20048334, PMID: 32571117). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Imetelstat | GRN163L|JNJ-63935937|GRN 163L | Imetelstat (GRN 163L) inhibits telomerase activity, resulting in telomere shortening and potentially leading to increased tumor cell death (PMID: 20048334, PMID: 32571117). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04576156 | Phase III | Thalidomide Danazol Hydroxyurea Imetelstat | A Study Comparing Imetelstat Versus Best Available Therapy for the Treatment of Intermediate-2 or High-risk Myelofibrosis (MF) Who Have Not Responded to Janus Kinase (JAK)-Inhibitor Treatment | Recruiting | USA | ITA | GBR | FRA | ESP | DEU | BEL | AUT | AUS | 17 |
| NCT05583552 | Phase II | Imetelstat | Study to Evaluate Imetelstat in Patients With High-Risk MDS or AML Failing HMA-based Therapy (IMpress) | Recruiting | FRA | DEU | AUS | 0 |
| NCT02598661 | Phase III | Imetelstat | Study to Evaluate Imetelstat (JNJ-63935937) in Subjects With International Prognostic Scoring System (IPSS) Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS) | Active, not recruiting | USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BEL | 8 |
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