Disease Detail

ID DOID:70004
Name myeloid neoplasm
Definition A bone marrow cancer that is formed of any one of the bone marrow cells belonging to the granulocytic (neutrophil, eosinophil, basophil), monocytic/macrophage, erythroid, megakaryocytic and mast cell lineages.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer hematologic cancer bone marrow cancer myeloid neoplasm

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
MET positive Amuvatinib myeloid neoplasm predicted - sensitive detail...
FGFR3 K650E FGFR3 over exp HRAS K117E AZ8010 myeloid neoplasm sensitive detail...
FGFR3 wild-type SSR128129E myeloid neoplasm sensitive detail...
FGFR3 K650E SSR128129E myeloid neoplasm no benefit detail...
FGFR3 Y373C Debio 1347 myeloid neoplasm sensitive detail...
FGFR3 K650E Debio 1347 myeloid neoplasm sensitive detail...
FGFR3 F386L Debio 1347 myeloid neoplasm sensitive detail...
FGFR3 wild-type SU5402 myeloid neoplasm sensitive detail...
FGFR3 K650E SU5402 myeloid neoplasm sensitive detail...
FGFR3 rearrange PRN1371 myeloid neoplasm sensitive detail...
FGFR3 Y373C RO4987655 myeloid neoplasm no benefit detail...
FGFR3 Y373C RO5126766 myeloid neoplasm no benefit detail...
FGFR3 Y373C Selumetinib myeloid neoplasm no benefit detail...
FGFR3 rearrange AZD4547 myeloid neoplasm sensitive detail...
Unknown unknown Bortezomib + Dexamethasone + Lenalidomide myeloid neoplasm not applicable detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT01885897 Phase Ib/II ALT-803 IL-15 Super Agonist ALT-803 to Treat Relapse Of Hematologic Malignancy After Allogeneic SCT Active, not recruiting
NCT02420860 Phase II Famotidine Elotuzumab + Lenalidomide Diphenhydramine Dexamethasone Study of Elotuzumab With Lenalidomide as Maintenance After Autologous Stem Cell Transplant (ASCT) Active, not recruiting
NCT02506959 Phase II Dexamethasone Busulfan + Melphalan Pyridoxine Panobinostat Palifermin Gemcitabine Panobinostat Combined With High-Dose Gemcitabine/Busulfan/Melphalan With Autologous Stem Cell Transplant for Patients With Refractory/Relapsed Myeloma Recruiting
NCT02843074 Phase II Dexamethasone + Elotuzumab + Lenalidomide Elotuzumab, Lenalidomide and Dexamethasone (ERd) in the Induction, Consolidation and Maintenance Treatment of Transplant-Eligible, Newly Diagnosed Multiple Myeloma Patients Recruiting
NCT02969837 Phase II Carfilzomib + Dexamethasone + Elotuzumab + Lenalidomide Study of Initial Treatment With Elotuzumab, Carfilzomib, Lenalidomide and Dexamethasone in Multiple Myeloma Recruiting
NCT03531918 Phase Ib/II Cladribine + Cytarabine + Filgrastim + Gemtuzumab ozogamicin + Mitoxantrone Cladribine + Cytarabine + Filgrastim Gemtuzumab Ozogamicin With G-CSF, Cladribine, Cytarabine and Mitoxantrone in Treating Participants With Previously Untreated Acute Myeloid Leukemia or High-Grade Myeloid Neoplasm Recruiting
NCT03862157 Phase Ib/II Azacitidine + MLN4924 + Venetoclax Azacitidine, Venetoclax, and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Recruiting