Therapy Detail

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Therapy Name TP-3654
Synonyms
Therapy Description

TP-3654 is an inhibitor of PIM1, PIM2, PIM3, and moderately inhibits FLT3, which may result in anti-tumor activity (PMID: 24953177).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
TP-3654 SGI-9481|SGI9481|TP3654 FLT3 Inhibitor 61 PIM Inhibitor (Pan) 9 TP-3654 (SGI-9481) is an inhibitor of PIM1, PIM2, PIM3, and moderately inhibits FLT3, which may result in anti-tumor activity (PMID: 24953177).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03715504 Phase I TP-3654 Phase I Study of TP-3654 in Patients With Advanced Solid Tumors Completed USA 0
NCT04176198 Phase I TP-3654 A Study of Oral TP-3654 in Patients With Myelofibrosis Recruiting USA 1


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