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Molecular Profile | BRAF V600D |
Therapy | Dabrafenib + Trametinib |
Indication/Tumor Type | ganglioglioma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600D | ganglioglioma | predicted - sensitive | Dabrafenib + Trametinib | Case Reports/Case Series | Actionable | In a clinical case study, treatment with the combination of Tafinlar (dabrafenib) and Mekinist (trametinib) resulted in a partial response in a pediatric patient with ganglioglioma harboring BRAF V600D (PMID: 38844796; NCT03336931). | 38844796 |
PubMed Id | Reference Title | Details |
---|---|---|
(38844796) | Precision-guided treatment in high-risk pediatric cancers. | Full reference... |