Disease Detail


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ID DOID:5078
Name ganglioglioma
Definition A cell type benign neoplasm that has_material_basis_in glial-type cells.
Source DiseaseOntology.org
Alt Ids DOID:5607 DOID:5606
Path disease disease of cellular proliferation benign neoplasm cell type benign neoplasm ganglioglioma


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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
BRAF V600E Dabrafenib ganglioglioma predicted - sensitive detail...
BRAF L514V BRAF V600E Dabrafenib ganglioglioma resistant detail...
BRAF V600X Dabrafenib ganglioglioma predicted - sensitive detail...
BRAF V600E Dabrafenib + Trametinib ganglioglioma sensitive detail...
BRAF V600E Cobimetinib + Vemurafenib ganglioglioma sensitive detail...
BRAF V600E Vemurafenib ganglioglioma predicted - sensitive detail...
BRAF T599dup Dabrafenib + Trametinib ganglioglioma predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01999270 Phase I Bevacizumab + Irinotecan Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS Tumors Completed USA 0
NCT03919071 Phase II Dabrafenib + Trametinib Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma Recruiting USA 1
NCT03975829 FDA approved Dabrafenib + Trametinib Pediatric Long-Term Follow-up and Rollover Study Recruiting USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUS 9
NCT04923126 Phase Ib/II PD-0325901 SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma Recruiting USA 0
NCT05503797 Phase II Cobicistat + PLX8394 PLX8394 A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations Recruiting USA | ITA | GBR | FRA | ESP | DEU | CAN 2