Profile Response Detail

Molecular Profile BRAF V600E
Therapy Trametinib + Navitoclax
Indication/Tumor Type colon cancer
Response Type sensitive
Create By c-seddy
Update By c-seddy

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E colon cancer sensitive Trametinib + Navitoclax Preclinical Actionable In a preclinical study, Navitoclax (ABT-263) enhanced the inhibitory effect of Mekinist (trametinib) on human colon cancer cells harboring BRAF V600E in culture (PMID: 25665005). 25665005
PubMed Id Reference Title Details
(25665005) The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies. Full reference...