Profile Response Detail

Molecular Profile TP53 R175H
Therapy Alvespimycin + Vorinostat
Indication/Tumor Type Advanced Solid Tumor
Response Type sensitive
Create By c-seddy
Update By c-seddy


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 R175H Advanced Solid Tumor sensitive Alvespimycin + Vorinostat Preclinical Actionable In a preclinical study, Alvespimycin (17-DMAG) and Zolinza (vorinostat) extended survival by 59% in mice with tumors expressing Tp53 R172H (which corresponds to R175H in the human Tp53 protein) (PMID: 26009011). 26009011
PubMed Id Reference Title Details
(26009011) Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment. Full reference...