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Molecular Profile PTEN dec exp
Therapy Pemetrexed Disodium + Sorafenib
Indication/Tumor Type Advanced Solid Tumor
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PTEN dec exp Advanced Solid Tumor predicted - sensitive Pemetrexed Disodium + Sorafenib Phase I Actionable In a Phase I clinical trial, low Pten expression or lack of Pten expression was associated with better response to treatment with the combination of Alimta (pemetrexed) and Nexavar (sorafenib) in patients with advanced solid tumors (PMID: 27213589). 27213589
PubMed Id Reference Title Details
(27213589) Phase I study of pemetrexed with sorafenib in advanced solid tumors. Full reference...