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Molecular Profile VHL inact mut
Therapy PT2399
Indication/Tumor Type clear cell renal cell carcinoma
Response Type conflicting


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
VHL inact mut clear cell renal cell carcinoma conflicting PT2399 Preclinical - Pdx Actionable In a preclinical study, PT2399 had variable impact on tumor growth in clear cell renal cell carcinoma (ccRCC) cell line and patient-derived xenograft (PDX) models with defective VHL, with decreased tumor growth in a VHL-defective ccRCC PDX model and some VHL-defective ccRCC cell line xenograft models, and no tumor suppression in other cell line xenograft models (PMID: 27595393). 27595393
PubMed Id Reference Title Details
(27595393) On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models. Full reference...