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ID DOID:4467
Name clear cell renal cell carcinoma
Definition A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer urinary system cancer kidney cancer renal carcinoma renal cell carcinoma clear cell renal cell carcinoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
VHL over exp Cediranib + Saracatinib clear cell renal cell carcinoma no benefit detail...
VHL inact mut PT2399 clear cell renal cell carcinoma conflicting detail...
TP53 R248W VHL inact mut PT2399 clear cell renal cell carcinoma resistant detail...
PBRM1 mutant Everolimus clear cell renal cell carcinoma conflicting detail...
PBRM1 inact mut Nivolumab clear cell renal cell carcinoma sensitive detail...
PBRM1 inact mut Ipilimumab + Nivolumab clear cell renal cell carcinoma sensitive detail...
PBRM1 inact mut Atezolizumab clear cell renal cell carcinoma sensitive detail...
PBRM1 Y331* Nivolumab clear cell renal cell carcinoma predicted - sensitive detail...
PBRM1 A249fs Nivolumab clear cell renal cell carcinoma no benefit detail...
PBRM1 E291* Nivolumab clear cell renal cell carcinoma no benefit detail...
PBRM1 G2fs Nivolumab clear cell renal cell carcinoma no benefit detail...
PBRM1 K135fs Nivolumab clear cell renal cell carcinoma predicted - sensitive detail...
PBRM1 K154fs Nivolumab clear cell renal cell carcinoma predicted - sensitive detail...
PBRM1 K619fs Ipilimumab + Nivolumab clear cell renal cell carcinoma predicted - sensitive detail...
PBRM1 K621* Nivolumab clear cell renal cell carcinoma no benefit detail...
PBRM1 N463fs Nivolumab clear cell renal cell carcinoma predicted - sensitive detail...
PBRM1 N609fs Nivolumab clear cell renal cell carcinoma no benefit detail...
PBRM1 R941fs Nivolumab clear cell renal cell carcinoma no benefit detail...
PBRM1 S681R Nivolumab clear cell renal cell carcinoma predicted - sensitive detail...
PBRM1 W141_L145delinsC Nivolumab clear cell renal cell carcinoma no benefit detail...
PBRM1 Y106* Ipilimumab + Nivolumab clear cell renal cell carcinoma predicted - sensitive detail...
PBRM1 Y608fs Nivolumab clear cell renal cell carcinoma no benefit detail...
PBRM1 mutant Nivolumab clear cell renal cell carcinoma predicted - sensitive detail...
TSC2 mutant N/A clear cell renal cell carcinoma not applicable detail...
TSC1 mutant N/A clear cell renal cell carcinoma not applicable detail...
VHL mutant N/A clear cell renal cell carcinoma not applicable detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT00747305 Phase I Sunitinib Sunitinib Before and After Surgery in Treating Patients With Metastatic Kidney Cancer That Can Be Removed By Surgery Terminated USA 0
NCT00831480 Phase II Everolimus Everolimus(RAD001) For Advanced Renal Cell Carcinoma(RCC)Before Kidney Removal Terminated USA 0
NCT01038778 Phase Ib/II Entinostat Aldesleukin Entinostat in Combination With Aldesleukin in Treating Patients With Metastatic Kidney Cancer Active, not recruiting USA 0
NCT01099423 Phase III Sunitinib Immediate Surgery or Surgery After Sunitinib Malate in Treating Patients With Metastatic Kidney Cancer Unknown status CAN 4
NCT01158521 Phase II Pazopanib Pazopanib Hydrochloride Before Surgery in Treating Patients With Kidney Cancer Completed USA 0
NCT01392183 Phase II Diphenhydramine Temsirolimus Pazopanib Pazopanib Versus Temsirolimus in Poor-Risk Clear-Cell Renal Cell Carcinoma (RCC) Completed USA 0
NCT01499121 Phase II Sunitinib Study of Efficacy and Safety of Sunitinib Given on an Individualized Schedule Completed CAN 0
NCT01582204 Phase I Pazopanib Sunitinib Evaluate The Utility Of 124I-cG250 for The Early Detection Of Response to Therapy In Patients With Metastatic Renal Cell Carcinoma Active, not recruiting USA 0
NCT01599754 Phase III Axitinib Adjuvant Axitinib Therapy of Renal Cell Cancer in High Risk Patients Terminated USA 8
NCT01599832 Phase I Pazopanib Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Measuring Effects of Pazopanib Hydrochloride in Patients With Metastatic Kidney Cancer Terminated USA 0
NCT01684397 Phase Ib/II Bevacizumab + Pazopanib Pazopanib Hydrochloride and Bevacizumab in Treating Patients With Previously Untreated Metastatic Kidney Cancer Recruiting USA 0
NCT01835158 Phase II Cabozantinib Cabozantinib + Sunitinib Cabozantinib-s-malate or Sunitinib Malate in Treating Patients With Previously Untreated Locally Advanced or Metastatic Kidney Cancer Completed USA 0
NCT01999972 Phase I Axitinib + Crizotinib A Phase 1b Study Of Axitinib In Combination With Crizotinib In Patients With Advanced Solid Tumors Completed USA 1
NCT02060370 Phase II Sunitinib Sunitinib Scheduling in Metastatic Renal Cell Carcinoma (mRCC) Completed USA 0
NCT02178722 Phase Ib/II Epacadostat + Pembrolizumab Study to Explore the Safety, Tolerability and Efficacy of MK-3475 in Combination With INCB024360 in Participants With Selected Cancers Completed USA 0
NCT02210117 Phase II Nivolumab Bevacizumab + Nivolumab Ipilimumab + Nivolumab Nivolumab vs Nivolumab + Bevacizumab vs Nivolumab + Ipilimumab in Metastatic Renal Cell Carcinoma (mRCC) Active, not recruiting USA 0
NCT02293980 Phase I PT2385 Nivolumab + PT2385 A Phase 1, Dose-Escalation Trial of PT2385 Tablets In Patients With Advanced Clear Cell Renal Cell Carcinoma Active, not recruiting USA 0
NCT02307474 Phase I Pazopanib A Pilot Study of SBRT With Adjuvant Pazopanib for Renal Cell Cancer Withdrawn USA 0
NCT02315066 Phase I PF-04518600 PF-04518600 + Utomilumab Study Of OX40 Agonist PF-04518600 Alone And In Combination With 4-1BB Agonist PF-05082566 Completed USA 3
NCT02348008 Phase Ib/II Bevacizumab + Pembrolizumab Phase Ib and Phase II Studies of MK-3475 in Combination + for Renal Cell Carcinoma Completed USA 0
NCT02386111 Phase Ib/II Sunitinib + Varlilumab A Study of Varlilumab (Anti-CD27) and Sunitinib in Patients With Metastatic Clear Cell Renal Cell Carcinoma Terminated USA 0
NCT02509507 Phase I Pembrolizumab + Talimogene laherparepvec Talimogene laherparepvec Trial to Evaluate the Safety of Talimogene Laherparepvec Injected Into Liver Tumors Alone and in Combination With Systemic Pembrolizumab Active, not recruiting USA 8
NCT02535533 Phase I Axitinib + Selenomethionine SLM + Axitinib for Clear Cell RCC Recruiting USA 0
NCT02540291 Phase I E7046 Study of E7046 in Subjects With Selected Advanced Malignancies Terminated USA 1
NCT02575222 Phase I Nivolumab Study of Neoadjuvant Nivolumab in Patients With Non-metastatic Stage II-IV Clear Cell Renal Cell Carcinoma Completed USA 0
NCT02579811 Phase II Axitinib Axitinib Given on an Individualized Schedule for Metastatic Renal Cell Cancer Active, not recruiting USA 0
NCT02595918 Phase I Nivolumab Nivolumab in Treating Patients With HIgh-Risk Non-Metastatic Kidney Cancer Terminated USA 0
NCT02599324 Phase Ib/II Cetuximab + Ibrutinib Ibrutinib + Paclitaxel Everolimus + Ibrutinib Docetaxel + Ibrutinib A Study to Evaluate Ibrutinib Combination Therapy in Patients With Selected Gastrointestinal and Genitourinary Tumors Completed USA 3
NCT02607553 Phase II Mipsagargin Safety and Activity of G-202 in Patients With Clear Cell Renal Cell Carcinoma That Expresses PSMA Completed USA 0
NCT02626130 Phase I Tremelimumab Pilot Study of Presurgical Tremelimumab With or Without Cryoablation in Patients With Metastatic Renal Cell Carcinoma (RCC) Active, not recruiting USA 0
NCT02628535 Phase I MGD009 Safety Study of MGD009 in B7-H3-expressing Tumors Terminated USA | CAN 1
NCT02667886 Phase Ib/II Axitinib X4P-001 Trial of X4P-001 in Patients With Advanced Renal Cell Carcinoma Active, not recruiting USA 1
NCT02837991 Phase Ib/II CDX-014 A Dose Escalation, Safety and Activity Study of CDX-014 in Patients With Advanced or Metastatic Renal Cell Carcinoma Terminated USA 0
NCT02853344 Phase II Pembrolizumab Study of Pembrolizumab (MK-3475) Monotherapy in Locally Advanced/Metastatic Renal Cell Carcinoma (MK-3475-427/KEYNOTE-427) Active, not recruiting 0
NCT02885649 Phase 0 Enzalutamide Enzalutamide Before Surgery in Treating Patients With Kidney Cancer Terminated USA 0
NCT02947165 Phase I NIS793 + Spartalizumab NIS793 Phase I/Ib Study of NIS793 in Combination With PDR001 in Patients With Advanced Malignancies. Completed USA | CAN 7
NCT02974738 Phase I Belzutifan A Trial of PT2977 Tablets In Patients With Advanced Solid Tumors Active, not recruiting 0
NCT02978404 Phase II Nivolumab Combining Radiosurgery and Nivolumab in the Treatment of Brain Metastases Active, not recruiting CAN 0
NCT02989714 Phase Ib/II Aldesleukin + Nivolumab Phase Ib/II Trial of Interleukin-2 and PD-1 Checkpoint Inhibitor, Nivolumab In Metastatic Clear Cell Renal Cell Cancer Completed USA 0
NCT03015740 Phase Ib/II MGCD516 + Nivolumab MGCD516 Combined With Nivolumab in Renal Cell Cancer (RCC) Active, not recruiting USA 0
NCT03024996 Phase III Atezolizumab A Study of Atezolizumab as Adjuvant Therapy in Participants With Renal Cell Carcinoma (RCC) at High Risk of Developing Metastasis Following Nephrectomy (IMmotion010) Active, not recruiting USA | CAN 26
NCT03035630 Phase II Avelumab Sunitinib Sunitinib Followed by Avelumab or the Reverse for Metastatic Renal Cell Carcinoma Withdrawn USA 0
NCT03108066 Phase II PT2385 PT2385 for the Treatment of Von Hippel-Lindau Disease-Associated Clear Cell Renal Cell Carcinoma Active, not recruiting USA 0
NCT03138512 Phase III Ipilimumab + Nivolumab A Study Comparing the Combination of Nivolumab and Ipilimumab Versus Placebo in Participants With Localized Renal Cell Carcinoma (CheckMate 914) Recruiting USA | CAN 23
NCT03141177 Phase III Cabozantinib + Ipilimumab + Nivolumab Sunitinib Cabozantinib + Nivolumab A Study of Nivolumab Combined With Cabozantinib or Nivolumab and Ipilimumab Combined With Cabozantinib Compared to Sunitinib in Previously Untreated Advanced or Metastatic Renal Cell Carcinoma (CheckMate 9ER) Active, not recruiting USA 17
NCT03149159 Phase II Ipilimumab + Nivolumab Investigator-Initiated Trial of Combined Ipilimumab, Nivolumab and Stereotactic Radiation in Patients With Metastatic Clear-Cell RCC (ccRCC) Who Have Failed Treatment With Single-Agent Nivolumab Withdrawn USA 0
NCT03170960 Phase Ib/II Atezolizumab + Cabozantinib Study of Cabozantinib in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors Recruiting USA 8
NCT03173560 Phase II Everolimus + Lenvatinib Trial to Assess Safety and Efficacy of Lenvatinib in Combination With Everolimus in Participants With Renal Cell Carcinoma Active, not recruiting USA | CAN 14
NCT03200717 Phase II Pazopanib Study of Efficacy, Safety, and Quality of Life of Pazopanib in Patients With Advanced and/or Metastatic Renal Cell Carcinoma After Prior Checkpoint Inhibitor Treatment Completed USA | CAN 9
NCT03260504 Phase I Aldesleukin + Pembrolizumab Aldesleukin and Pembrolizumab in Treating Patients With Advanced or Metastatic Kidney Cancer Recruiting USA 0
NCT03284385 Phase II Adavosertib Testing AZD1775 in Advanced Solid Tumors That Have a Mutation Called SETD2 Recruiting USA 0
NCT03294083 Phase I Cemiplimab + JX-594 A Study of Recombinant Vaccinia Virus in Combination With REGN2810 for Renal Cell Carcinoma Recruiting USA 2
NCT03308396 Phase Ib/II Durvalumab + Guadecitabine Guadecitabine Study of Durvalumab and Guadecitabine in Advanced Kidney Cancer Active, not recruiting USA 0
NCT03334409 Phase II Pazopanib Pazopanib Hydrochloride With or Without Ascorbic Acid in Treating Patients With Kidney Cancer That Is Metastatic or Cannot Be Removed by Surgery Terminated USA 0
NCT03354390 Phase I Autologous HERV-E TCR transduced T cells HERV-E TCR Transduced Autologous T Cells in People With Metastatic Clear Cell Renal Cell Carcinoma Recruiting USA 0
NCT03438708 Phase II Axitinib Prior Axitinib as a Determinant of Outcome of Renal Surgery (PADRES) Unknown status USA 0
NCT03629756 Phase I AB928 + GLS-010 A Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants With Advanced Malignancies Completed USA 1
NCT03680521 Phase II MGCD516 + Nivolumab Neoadjuvant Sitravatinib in Combination With Nivolumab in Patients With Clear Cell Renal Cell Carcinoma Active, not recruiting USA 0
NCT03682289 Phase II Ceralasertib + Olaparib Olaparib Phase II Trial of AZD6738 Alone and in Combination With Olaparib Recruiting USA 0
NCT03693612 Phase Ib/II GSK3359609 + Tremelimumab Paclitaxel Docetaxel Cetuximab GSK3359609 Plus Tremelimumab for the Treatment of Advanced Solid Tumors Completed USA | CAN 1
NCT03815682 Phase I Pembrolizumab + RPTR-147 RPTR-147 RPTR-147 in Patients With Selected Solid Tumors and Lymphomas Recruiting USA 0
NCT03829111 Phase I Ipilimumab + Nivolumab CBM588 + Ipilimumab + Nivolumab CBM588, Nivolumab, and Ipilimumab in Treating Patients With Stage IV or Advanced Kidney Cancer Recruiting USA 0
NCT03875313 Phase Ib/II Talazoparib + Telaglenastat Study of CB-839 (Telaglenastat) in Combination With Talazoparib in Patients With Solid Tumors Terminated USA 0
NCT03937219 Phase III Cabozantinib + Nivolumab Ipilimumab + Nivolumab Cabozantinib + Ipilimumab + Nivolumab Study of Cabozantinib in Combination With Nivolumab and Ipilimumab in Patients With Previously Untreated Advanced or Metastatic Renal Cell Carcinoma (COSMIC-313) Active, not recruiting USA | CAN 23
NCT04028245 Phase I Canakinumab + Spartalizumab A Study of Combination Spartalizumab and Canakinumab in Patients With Localized Clear Cell Renal Cell Carcinoma (SPARC-1) Recruiting USA 0
NCT04071223 Phase II Cabozantinib + Radium Ra 223 dichloride Cabozantinib Testing the Addition of a New Anti-cancer Drug, Radium-223 Dichloride, to the Usual Treatment (Cabozantinib) for Advanced Renal Cell Cancer That Has Spread to the Bone, the RadiCaL Study Recruiting USA 0
NCT04150562 Phase II Avelumab + rhIL-15 Avelumab (Bavencio) With IL-15 in Subjects With Clear-Cell Renal Carcinoma Completed USA 0
NCT04152018 Phase I PF-06801591 + PF-06940434 PF-06940434 Study of PF-06940434 in Patients With Advanced or Metastatic Solid Tumors. Recruiting USA 0
NCT04169711 Phase I ARO-HIF2 Study of ARO-HIF2 in Patients With Advanced Clear Cell Renal Cell Carcinoma Recruiting USA 0
NCT04169841 Phase II Durvalumab + Olaparib + Tremelimumab Study Evaluating the Efficacy of a Double Immunotherapy Combined With Olaparib in Patients With Solid Cancers and Carriers of Homologous Recombination Repair Genes After Olaparib Treatment (GUIDE2REPAIR) Recruiting 1
NCT04195750 Phase III Belzutifan Everolimus A Study of MK-6482 Versus Everolimus in Participants With Advanced Renal Cell Carcinoma (MK-6482-005) Recruiting USA | CAN 21
NCT04276376 Phase II Atezolizumab + Rucaparib Efficacy and Safety of the Combination of Rucaparib (PARP Inhibitor) and Atezolizumab (Anti-PD-L1 Antibody) in Patients With DNA Repair-deficient or Platinum-sensitive Solid Tumors (ARIANES) Recruiting 1
NCT04300140 Phase Ib/II AVB-S6-500 + Cabozantinib Cabozantinib Efficacy and Safety Study of AVB-S6-500 in Patients With Clear Cell Renal Cell Carcinoma Recruiting USA 0
NCT04338269 Phase III Cabozantinib Atezolizumab + Cabozantinib A Study of Atezolizumab in Combination With Cabozantinib Compared to Cabozantinib Alone in Participants With Advanced Renal Cell Carcinoma After Immune Checkpoint Inhibitor Treatment (CONTACT-03) Recruiting USA | CAN 13
NCT04374877 Phase I SRF388 Study of SRF388 in Patients With Advanced Solid Tumors Recruiting USA 2
NCT04388852 Phase I DS-3201b + Ipilimumab DS3201 and Ipilimumab for the Treatment of Metastatic Prostate, Urothelial and Renal Cell Cancers Recruiting USA 0
NCT04504669 Phase I AZD8701 + Durvalumab AZD8701 First Time in Human Study of AZD8701 With or Without Durvalumab in Participants With Advanced Solid Tumours Recruiting USA | CAN 2
NCT04518046 Phase I Ipilimumab + MGCD516 + Nivolumab Study of Sitravatinib, Nivolumab and Ipilimumab in Advanced or Metastatic Clear-Cell Renal Cell Carcinoma or Other Solid Malignancies Recruiting USA 0
NCT04521413 Phase Ib/II CFI-402411 + Pembrolizumab CFI-402411 Safety and Efficacy Study Of CFI-402411 in Subjects With Advanced Solid Malignancies Recruiting USA | CAN 1
NCT04586231 Phase III Belzutifan + Lenvatinib Cabozantinib A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011) Recruiting USA 12
NCT04626479 Phase Ib/II Lenvatinib + MK-1308A Lenvatinib + MK-4280A Lenvatinib + Pembrolizumab Belzutifan + Lenvatinib + Pembrolizumab Substudy 03A: A Study of Immune and Targeted Combination Therapies in Participants With First Line (1L) Renal Cell Carcinoma (MK-3475-03A) Recruiting USA | CAN 7
NCT04626518 Phase Ib/II MK-4280A Lenvatinib + Pembrolizumab Belzutifan + Pembrolizumab MK-1308A MK-4830 + Pembrolizumab Belzutifan + Lenvatinib Substudy 03B: A Study of Immune and Targeted Combination Therapies in Participants With Second Line Plus (2L+) Renal Cell Carcinoma (MK-3475-03B) Recruiting USA | CAN 7
NCT04627064 Phase I Abemaciclib + Belzutifan Abemaciclib ABEMA Alone or in COMBO With MK-6482 Recruiting USA 0
NCT04691375 Phase I Pembrolizumab + PY314 PY314 A Study of PY314 in Subjects With Advanced Solid Tumors Recruiting USA 0
NCT04777994 Phase I ABBV-CLS-484 + unspecified PD-1 antibody ABBV-CLS-484 A Phase 1 Study With ABBV-CLS-484 in Subjects With Locally Advanced or Metastatic Tumors Recruiting USA 2
NCT04834778 Phase I HC-5404-FU A Study of HC-5404-FU to Establish the Maximum Tolerated Dose (MTD) Recruiting USA 0
NCT04904302 Phase II MGCD516 + Nivolumab Sitravatinib and Nivolumab for the Treatment of Metastatic or Advanced Clear Cell Renal Cell Cancer Not yet recruiting USA 0
NCT05006794 Phase I GS-9716 + Sacituzumab govitecan-hziy GS-9716 Docetaxel + GS-9716 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of GS-9716 as Monotherapy and in Combination With Anticancer Therapies in Adults With Solid Malignancies Recruiting USA 0