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Therapy Name 177Lu-rhPSMA-10.1
Synonyms
Therapy Description

177Lu-rhPSMA-10.1 is a radioconjugate comprising the radionuclide lutetium-177 linked to a PSMA-targeted ligand, PSMA-10.1, which delivers radiation to PSMA-expressing tumor cells, potentially resulting in increased tumor cell death and antitumor activity (PMID: 36692961, NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
177Lu-rhPSMA-10.1 177Lu rhPSMA-10.1|(177Lu) rhPSMA-10.1|Lutetium Lu 177 PSMA-10.1 177Lu-rhPSMA-10.1 is a radioconjugate comprising the radionuclide lutetium-177 linked to a PSMA-targeted ligand, PSMA-10.1, which delivers radiation to PSMA-expressing tumor cells, potentially resulting in increased tumor cell death and antitumor activity (PMID: 36692961, NCI Drug Dictionary).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06105918 Phase I 177Lu-rhPSMA-10.1 Radioligand Therapy After PSMA PET Guided External Beam Radiotherapy for Treating Post-Prostatectomy Patients With Biochemically Recurrent Prostate Cancer Recruiting USA 0
NCT06059014 Phase Ib/II 177Lu-rhPSMA-10.1 Phase I/II Study Evaluating PSMA Targeted Radionuclide Therapy in Adult Patients With Metastatic Clear Cell Renal Cancer (PRadR) Recruiting FRA 0
NCT05413850 Phase Ib/II 177Lu-rhPSMA-10.1 Anti-tumour Activity of (177Lu) rhPSMA-10.1 Injection Recruiting USA | NLD 0


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