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Molecular Profile | PDGFRB P584R |
Therapy | Nilotinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PDGFRB P584R | Advanced Solid Tumor | sensitive | Nilotinib | Preclinical - Cell culture | Actionable | In a preclinical study, Tasigna (nilotinib) inhibited PDGFRB downstream signaling and proliferation of transformed cells expressing PDGFRB P584R in culture (PMID: 26455322). | 26455322 |
PubMed Id | Reference Title | Details |
---|---|---|
(26455322) | PDGFRB mutants found in patients with familial infantile myofibromatosis or overgrowth syndrome are oncogenic and sensitive to imatinib. | Full reference... |