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Ref Type Journal Article
PMID (23248156)
Authors Janku F, Wheler JJ, Naing A, Stepanek VM, Falchook GS, Fu S, Garrido-Laguna I, Tsimberidou AM, Piha-Paul SA, Moulder SL, Lee JJ, Luthra R, Hong DS, Kurzrock R
Title PIK3CA mutations in advanced cancers: characteristics and outcomes.
Journal Oncotarget
Vol 3
Issue 12
Date 2012 Dec
URL
Abstract Text PIK3CA mutations are frequently diagnosed in diverse cancers and may predict response to PI3K/AKT/mTOR inhibitors. It remains unclear whether they are associated with other characteristics. We analyzed characteristics and outcome of 90 consecutive patients with diverse advanced tumors and PIK3CA mutations and 180 wild-type PIK3CA controls matched by tumor type, gender, and age referred to the Clinical Center for Targeted Therapy. PIK3CA and MAPK mutations (KRAS, NRAS, and BRAF) were analyzed using polymerase chain reaction-based DNA sequencing. The most frequent PIK3CA mutations were E545K (31/90, 34%), E542K (16/90, 18%) in exon 9, and H1047R (20/90, 22%) in exon 20. PIK3CA mutations compared to wild-type PIK3CA were associated with simultaneous KRAS (p=0.047) and MAPK mutations (p=0.03), but only MAPK mutations were confirmed as having an independent association in multivariate analysis. Rates of lung, bone, liver and brain metastases were similar in PIK3CA-mutant and wild-type patients. Patients with PIK3CA mutations treated on trials with PI3K/AKT/mTOR inhibitors had a higher partial/complete response (PR/CR) rate than wild-type PIK3CA patients treated with their best phase I therapy (10/56, 18% vs. 12/152, 8%; p=0.045), but not a prolonged progression-free survival. Patients with H1047R PIK3CA mutations had higher PR/CR rate with PI3K/AKT/mTOR inhibitors compared to wild-type PIK3CA patients treated with their best phase I therapy (6/16, 38% vs. 12/152, 8%; p=0.003). In conclusion, PIK3CA mutations in diverse cancers were not associated with clinical characteristics, but were correlated with MAPK mutations. PIK3CA mutations, especially, H1047R, were associated with attaining a PR/CR to PI3K/AKT/mTOR pathway inhibitors.

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Molecular Profile Treatment Approach
PIK3CA E542K Akt2 Inhibitor
PIK3CA E726K Akt2 Inhibitor
PIK3CA E542G PI3K Inhibitor (Pan)
PIK3CA R93P Akt2 Inhibitor
PIK3CA Q546K mTORC2 Inhibitor
PIK3CA E453A Akt2 Inhibitor
PIK3CA E545K PIK3CA inhibitor
PIK3CA N1044K Akt Inhibitor (Pan)
PIK3CA P449T mTORC1 Inhibitor
PIK3CA P449_L455del PI3K Inhibitor (Pan)
PIK3CA E545G mTORC2 Inhibitor
PIK3CA C901F PIK3CA inhibitor
PIK3CA P471L Akt Inhibitor (Pan)
PIK3CA L938* Akt2 Inhibitor
PIK3CA N1068fs PIK3CA inhibitor
PIK3CA V955G Akt2 Inhibitor
PIK3CA H1047R mTORC1 Inhibitor
PIK3CA E542K Akt1 Inhibitor
PIK3CA H1047P mTORC2 Inhibitor
PIK3CA E726K PIK3CA inhibitor
PIK3CA G106_R108del Akt1 Inhibitor
PIK3CA H1047X mTOR Inhibitor
PIK3CA G451V Akt Inhibitor (Pan)
PIK3CA G118D Akt1 Inhibitor
PIK3CA F930S mTORC2 Inhibitor
PIK3CA N345T mTORC1 Inhibitor
PIK3CA F930S Akt1 Inhibitor
PIK3CA G364R mTOR Inhibitor
PIK3CA G106R mTOR Inhibitor
PIK3CA P449T Akt Inhibitor (Pan)
PIK3CA R93P PIK3CA inhibitor
PIK3CA R108H mTORC1 Inhibitor
PIK3CA Y1021C Akt1 Inhibitor
PIK3CA E545D PIK3CA inhibitor
PIK3CA N345I Akt1 Inhibitor
PIK3CA C378R PI3K Inhibitor (Pan)
PIK3CA C604R PIK3CA inhibitor
PIK3CA V952A mTOR Inhibitor
PIK3CA E103_P104del Akt2 Inhibitor
PIK3CA E545D Akt1 Inhibitor
PIK3CA C378R mTORC1 Inhibitor
PIK3CA N345T Akt1 Inhibitor
PIK3CA E110del PI3K Inhibitor (Pan)
PIK3CA V955G mTORC2 Inhibitor
PIK3CA G451V PI3K Inhibitor (Pan)
PIK3CA T1025S mTORC2 Inhibitor
PIK3CA N345K Akt Inhibitor (Pan)
PIK3CA P449_L455del PIK3CA inhibitor
PIK3CA E453K Akt Inhibitor (Pan)
PIK3CA P366R Akt Inhibitor (Pan)
PIK3CA I910V Akt1 Inhibitor
PIK3CA R108C mTORC1 Inhibitor
PIK3CA E545G mTORC1 Inhibitor
PIK3CA E109_I112delinsD PIK3CA inhibitor
PIK3CA E453Q mTORC1 Inhibitor
PIK3CA V344M mTORC2 Inhibitor
PIK3CA G1049R mTOR Inhibitor
PIK3CA M1043I mTOR Inhibitor
PIK3CA E109_I112delinsD Akt Inhibitor (Pan)
PIK3CA E545X mTORC1 Inhibitor
PIK3CA T1025A Akt Inhibitor (Pan)
PIK3CA N1068Kfs*5 Akt2 Inhibitor
PIK3CA N345I Akt2 Inhibitor
PIK3CA G118D mTORC2 Inhibitor
PIK3CA H450_P458del PIK3CA inhibitor
PIK3CA K944N PIK3CA inhibitor
PIK3CA H1047X Akt Inhibitor (Pan)
PIK3CA R38C mTORC2 Inhibitor
PIK3CA Y1021C mTORC1 Inhibitor
PIK3CA P449_L455del mTOR Inhibitor
PIK3CA N345I mTORC2 Inhibitor
PIK3CA K111del PI3K Inhibitor (Pan)
PIK3CA E39K PIK3CA inhibitor
PIK3CA C378Y PI3K Inhibitor (Pan)
PIK3CA L938* Akt1 Inhibitor
PIK3CA H450_P458del mTOR Inhibitor
PIK3CA P449_N457del Akt1 Inhibitor
PIK3CA E726K Akt1 Inhibitor
PIK3CA E542V Akt2 Inhibitor
PIK3CA P366R Akt1 Inhibitor
PIK3CA G364R Akt1 Inhibitor
PIK3CA N1068fs mTORC2 Inhibitor
PIK3CA I910V PIK3CA inhibitor
PIK3CA C901F PI3K Inhibitor (Pan)
PIK3CA R38C Akt1 Inhibitor
PIK3CA P471L mTORC1 Inhibitor
PIK3CA E545X PIK3CA inhibitor
PIK3CA Q546L mTORC2 Inhibitor
PIK3CA P447_L455del mTOR Inhibitor
PIK3CA E453K mTORC1 Inhibitor
PIK3CA H1047L Akt2 Inhibitor
PIK3CA M1043I mTORC1 Inhibitor
PIK3CA H1047X PI3K Inhibitor (Pan)
PIK3CA P447_L455del Akt1 Inhibitor
PIK3CA K966E Akt1 Inhibitor
PIK3CA E453A Akt Inhibitor (Pan)
PIK3CA M1043V Akt2 Inhibitor
PIK3CA H1047P Akt Inhibitor (Pan)
PIK3CA V344M PIK3CA inhibitor
PIK3CA D350N mTORC1 Inhibitor
PIK3CA V952A Akt Inhibitor (Pan)
PIK3CA P449_N457del Akt2 Inhibitor
PIK3CA S629C mTOR Inhibitor
PIK3CA E542A Akt1 Inhibitor
PIK3CA G451V PIK3CA inhibitor
PIK3CA R108H Akt2 Inhibitor
PIK3CA P124L Akt1 Inhibitor
PIK3CA act mut PI3K Inhibitor (Pan)
PIK3CA V105_R108del PIK3CA inhibitor
PIK3CA D1029Y Akt1 Inhibitor
PIK3CA E545K mTORC2 Inhibitor
PIK3CA V952A Akt1 Inhibitor
PIK3CA G106R PIK3CA inhibitor
PIK3CA D939G Akt Inhibitor (Pan)
PIK3CA N1068Kfs*5 Akt1 Inhibitor
PIK3CA I112N mTOR Inhibitor
PIK3CA D1029Y mTORC2 Inhibitor
PIK3CA K944N mTORC2 Inhibitor
PIK3CA H1047K mTORC2 Inhibitor
PIK3CA E469delinsDK PIK3CA inhibitor
PIK3CA E1037K Akt2 Inhibitor
PIK3CA H1047L mTOR Inhibitor
PIK3CA E109_I112delinsD mTORC1 Inhibitor
PIK3CA E103_G106delinsD mTORC2 Inhibitor
PIK3CA E545G mTOR Inhibitor
PIK3CA V105_R108del mTORC2 Inhibitor
PIK3CA N345T mTORC2 Inhibitor
PIK3CA C420R PI3K Inhibitor (Pan)
PIK3CA N1068fs mTORC1 Inhibitor
PIK3CA E365V mTORC1 Inhibitor
PIK3CA Q546R mTORC2 Inhibitor
PIK3CA C420R mTORC1 Inhibitor
PIK3CA K111E PI3K Inhibitor (Pan)
PIK3CA M1004I mTOR Inhibitor
PIK3CA D1029Y PIK3CA inhibitor
PIK3CA T1025S PI3K Inhibitor (Pan)
PIK3CA M1004I PI3K Inhibitor (Pan)
PIK3CA K111N PI3K Inhibitor (Pan)
PIK3CA D939G mTORC1 Inhibitor
PIK3CA R88Q mTORC2 Inhibitor
PIK3CA V955I PI3K Inhibitor (Pan)
PIK3CA R93P mTORC1 Inhibitor
PIK3CA K111E mTORC2 Inhibitor
PIK3CA C378R Akt Inhibitor (Pan)
PIK3CA E726K Akt Inhibitor (Pan)
PIK3CA C971R mTOR Inhibitor
PIK3CA D549N PI3K Inhibitor (Pan)
PIK3CA E110del mTORC1 Inhibitor
PIK3CA E453Q Akt2 Inhibitor
PIK3CA E542G mTOR Inhibitor
PIK3CA P104L Akt2 Inhibitor
PIK3CA P449_N457del Akt Inhibitor (Pan)
PIK3CA H1047R Akt2 Inhibitor
PIK3CA E545Q Akt1 Inhibitor
PIK3CA P447_L455del PIK3CA inhibitor
PIK3CA N1068Kfs*5 mTORC1 Inhibitor
PIK3CA C971R Akt1 Inhibitor
PIK3CA S629C Akt2 Inhibitor
PIK3CA N1044K PI3K Inhibitor (Pan)
PIK3CA H1047R mTORC2 Inhibitor
PIK3CA R108H Akt Inhibitor (Pan)
PIK3CA E542G Akt2 Inhibitor
PIK3CA Q546R mTOR Inhibitor
PIK3CA N345K PI3K Inhibitor (Pan)
PIK3CA act mut mTORC1 Inhibitor
PIK3CA H1047Q PI3K Inhibitor (Pan)
PIK3CA D350N Akt Inhibitor (Pan)
PIK3CA P124L mTORC2 Inhibitor
PIK3CA D1029Y Akt2 Inhibitor
PIK3CA M1043V mTORC2 Inhibitor
PIK3CA E542A mTORC1 Inhibitor
PIK3CA Y1021C Akt Inhibitor (Pan)
PIK3CA C378Y Akt1 Inhibitor
PIK3CA V344M Akt2 Inhibitor
PIK3CA E545A Akt Inhibitor (Pan)
PIK3CA V344G mTORC2 Inhibitor
PIK3CA D1029Y mTORC1 Inhibitor
PIK3CA K944N Akt2 Inhibitor
PIK3CA P366R Akt2 Inhibitor
PIK3CA C901F mTORC1 Inhibitor
PIK3CA V955G PIK3CA inhibitor
PIK3CA I112N mTORC2 Inhibitor
PIK3CA P104L mTOR Inhibitor
PIK3CA M1043I Akt2 Inhibitor
PIK3CA G1049R Akt2 Inhibitor
PIK3CA C378R mTOR Inhibitor
PIK3CA C971R PI3K Inhibitor (Pan)
PIK3CA K111del mTOR Inhibitor
PIK3CA D549N PIK3CA inhibitor
PIK3CA G1007R PIK3CA inhibitor
PIK3CA N345K Akt2 Inhibitor
PIK3CA H1047Q PIK3CA inhibitor
PIK3CA K111E Akt1 Inhibitor
PIK3CA E453K Akt2 Inhibitor
PIK3CA E542A Akt2 Inhibitor
PIK3CA T1025N Akt2 Inhibitor
PIK3CA K111del Akt2 Inhibitor
PIK3CA N1068fs PI3K Inhibitor (Pan)
PIK3CA Q546R PIK3CA inhibitor
PIK3CA S629C mTORC1 Inhibitor
PIK3CA G106_R108del PIK3CA inhibitor
PIK3CA I112N mTORC1 Inhibitor
PIK3CA G118D PIK3CA inhibitor
PIK3CA E103_G106delinsD mTOR Inhibitor
PIK3CA Q546K PI3K Inhibitor (Pan)
PIK3CA E103_G106delinsD Akt2 Inhibitor
PIK3CA T1025S mTORC1 Inhibitor
PIK3CA L938* PIK3CA inhibitor
PIK3CA E469delinsDK mTORC2 Inhibitor
PIK3CA P449_L455del mTORC2 Inhibitor
PIK3CA R93P Akt1 Inhibitor
PIK3CA H1047K Akt1 Inhibitor
PIK3CA E1037K Akt1 Inhibitor
PIK3CA H1047X mTORC2 Inhibitor
PIK3CA G1049R mTORC2 Inhibitor
PIK3CA H1047Q mTORC1 Inhibitor
PIK3CA E365K PI3K Inhibitor (Pan)
PIK3CA V344M mTOR Inhibitor
PIK3CA E542G Akt Inhibitor (Pan)
PIK3CA C971R Akt Inhibitor (Pan)
PIK3CA R108C Akt Inhibitor (Pan)
PIK3CA S629C mTORC2 Inhibitor
PIK3CA R108C mTORC2 Inhibitor
PIK3CA D350N Akt2 Inhibitor
PIK3CA N345T PI3K Inhibitor (Pan)
PIK3CA V955I mTORC2 Inhibitor
PIK3CA Q546P Akt2 Inhibitor
PIK3CA E542V PIK3CA inhibitor
PIK3CA H1047R PIK3CA inhibitor
PIK3CA Q546L PIK3CA inhibitor
PIK3CA P447_L455del mTORC1 Inhibitor
PIK3CA N1068fs Akt Inhibitor (Pan)
PIK3CA M1043I Akt Inhibitor (Pan)
PIK3CA R93W Akt Inhibitor (Pan)
PIK3CA E545A mTORC1 Inhibitor
PIK3CA E365V Akt Inhibitor (Pan)
PIK3CA N1068Kfs*5 PI3K Inhibitor (Pan)
PIK3CA D350G mTORC2 Inhibitor
PIK3CA D350G Akt Inhibitor (Pan)
PIK3CA E545Q PI3K Inhibitor (Pan)
PIK3CA G1007R mTORC2 Inhibitor
PIK3CA P449T mTOR Inhibitor
PIK3CA P449_L455del mTORC1 Inhibitor
PIK3CA C901F Akt Inhibitor (Pan)
PIK3CA K966E Akt Inhibitor (Pan)
PIK3CA C604R Akt1 Inhibitor
PIK3CA V344G mTORC1 Inhibitor
PIK3CA T1025N PIK3CA inhibitor
PIK3CA E365K mTOR Inhibitor
PIK3CA K111del PIK3CA inhibitor
PIK3CA P104L mTORC2 Inhibitor
PIK3CA E109_I112delinsD PI3K Inhibitor (Pan)
PIK3CA act mut mTOR Inhibitor
PIK3CA Q546K mTORC1 Inhibitor
PIK3CA C378R Akt2 Inhibitor
PIK3CA P104L PI3K Inhibitor (Pan)
PIK3CA D939G PIK3CA inhibitor
PIK3CA E542K PI3K Inhibitor (Pan)
PIK3CA E542G mTORC2 Inhibitor
PIK3CA R88Q Akt1 Inhibitor
PIK3CA H1047K mTORC1 Inhibitor
PIK3CA K111N Akt Inhibitor (Pan)
PIK3CA E453K mTOR Inhibitor
PIK3CA Y1021C mTOR Inhibitor
PIK3CA R115L PIK3CA inhibitor
PIK3CA Q546E Akt2 Inhibitor
PIK3CA D1029Y PI3K Inhibitor (Pan)
PIK3CA E545Q mTORC2 Inhibitor
PIK3CA N345T mTOR Inhibitor
PIK3CA H1047K Akt Inhibitor (Pan)
PIK3CA H1047Y mTOR Inhibitor
PIK3CA E545Q Akt Inhibitor (Pan)
PIK3CA E469delinsDK mTOR Inhibitor
PIK3CA E545V PIK3CA inhibitor
PIK3CA H1047L PI3K Inhibitor (Pan)
PIK3CA V105_R108del Akt Inhibitor (Pan)
PIK3CA T1025A PI3K Inhibitor (Pan)
PIK3CA C971R Akt2 Inhibitor
PIK3CA K111del mTORC2 Inhibitor
PIK3CA D350G PI3K Inhibitor (Pan)
PIK3CA P447_L455del Akt Inhibitor (Pan)
PIK3CA K111N mTORC2 Inhibitor
PIK3CA P124L PIK3CA inhibitor
PIK3CA D350N PI3K Inhibitor (Pan)
PIK3CA D350N Akt1 Inhibitor
PIK3CA I910V PI3K Inhibitor (Pan)
PIK3CA G106V PI3K Inhibitor (Pan)
PIK3CA M1043L Akt1 Inhibitor
PIK3CA T1025A Akt2 Inhibitor
PIK3CA P539R PI3K Inhibitor (Pan)
PIK3CA E542K mTOR Inhibitor
PIK3CA R38C Akt2 Inhibitor
PIK3CA C378R mTORC2 Inhibitor
PIK3CA H1047R mTOR Inhibitor
PIK3CA E726K mTORC1 Inhibitor
PIK3CA R38C mTOR Inhibitor
PIK3CA R88Q PI3K Inhibitor (Pan)
PIK3CA P104L Akt1 Inhibitor
PIK3CA V105_R108del PI3K Inhibitor (Pan)
PIK3CA G106V Akt Inhibitor (Pan)
PIK3CA C420R mTOR Inhibitor
PIK3CA K944N mTORC1 Inhibitor
PIK3CA act mut mTORC2 Inhibitor
PIK3CA C604R mTOR Inhibitor
PIK3CA R108C Akt2 Inhibitor
PIK3CA E109_I112delinsD mTOR Inhibitor
PIK3CA Q546P PIK3CA inhibitor
PIK3CA H1047X PIK3CA inhibitor
PIK3CA H1047Y PIK3CA inhibitor
PIK3CA K111del Akt Inhibitor (Pan)
PIK3CA C971R mTORC2 Inhibitor
PIK3CA H1047P mTORC1 Inhibitor
PIK3CA Q546P Akt Inhibitor (Pan)
PIK3CA E453K PI3K Inhibitor (Pan)
PIK3CA G1007R mTOR Inhibitor
PIK3CA G451V Akt2 Inhibitor
PIK3CA R38H Akt Inhibitor (Pan)
PIK3CA E545V mTORC1 Inhibitor
PIK3CA E545A Akt1 Inhibitor
PIK3CA N1068Kfs*5 mTOR Inhibitor
PIK3CA C604R Akt Inhibitor (Pan)
PIK3CA R38H mTOR Inhibitor
PIK3CA G106R mTORC2 Inhibitor
PIK3CA G118D Akt Inhibitor (Pan)
PIK3CA C378Y PIK3CA inhibitor
PIK3CA E545Q mTOR Inhibitor
PIK3CA G106R PI3K Inhibitor (Pan)
PIK3CA E545K Akt2 Inhibitor
PIK3CA R38H mTORC2 Inhibitor
PIK3CA G106_R108del Akt2 Inhibitor
PIK3CA E39K mTORC2 Inhibitor
PIK3CA E39K mTORC1 Inhibitor
PIK3CA F930S PI3K Inhibitor (Pan)
PIK3CA P124L mTORC1 Inhibitor
PIK3CA V344G Akt2 Inhibitor
PIK3CA E545Q PIK3CA inhibitor
PIK3CA R88Q Akt Inhibitor (Pan)
PIK3CA C971R PIK3CA inhibitor
PIK3CA G451V mTORC2 Inhibitor
PIK3CA P124L Akt Inhibitor (Pan)
PIK3CA G118D PI3K Inhibitor (Pan)
PIK3CA H1047Q mTOR Inhibitor
PIK3CA R38C PI3K Inhibitor (Pan)
PIK3CA D1029Y Akt Inhibitor (Pan)
PIK3CA R108C PI3K Inhibitor (Pan)
PIK3CA R115L mTORC2 Inhibitor
PIK3CA K111del mTORC1 Inhibitor
PIK3CA E453K mTORC2 Inhibitor
PIK3CA E542A mTOR Inhibitor
PIK3CA N1044K Akt1 Inhibitor
PIK3CA M1043V PI3K Inhibitor (Pan)
PIK3CA E453Q Akt Inhibitor (Pan)
PIK3CA H1047R PI3K Inhibitor (Pan)
PIK3CA P104L Akt Inhibitor (Pan)
PIK3CA T1025S Akt Inhibitor (Pan)
PIK3CA N1068fs Akt1 Inhibitor
PIK3CA D350N PIK3CA inhibitor
PIK3CA V105_R108del Akt2 Inhibitor
PIK3CA Q546L Akt2 Inhibitor
PIK3CA E453Q mTOR Inhibitor
PIK3CA G1007R mTORC1 Inhibitor
PIK3CA E545X mTORC2 Inhibitor
PIK3CA E39K Akt2 Inhibitor
PIK3CA E110del Akt2 Inhibitor
PIK3CA M1043V mTORC1 Inhibitor
PIK3CA E545D Akt2 Inhibitor
PIK3CA Q546P Akt1 Inhibitor
PIK3CA H450_P458del PI3K Inhibitor (Pan)
PIK3CA H1047X Akt1 Inhibitor
PIK3CA R108C PIK3CA inhibitor
PIK3CA E542K mTORC1 Inhibitor
PIK3CA R93W Akt1 Inhibitor
PIK3CA E542G Akt1 Inhibitor
PIK3CA V955I Akt2 Inhibitor
PIK3CA E110del Akt1 Inhibitor
PIK3CA K966E mTORC1 Inhibitor
PIK3CA I112N PI3K Inhibitor (Pan)
PIK3CA C420R Akt Inhibitor (Pan)
PIK3CA K111del Akt1 Inhibitor
PIK3CA N345I PI3K Inhibitor (Pan)
PIK3CA C901F mTOR Inhibitor
PIK3CA E545G Akt1 Inhibitor
PIK3CA M1043L Akt2 Inhibitor
PIK3CA V344M Akt Inhibitor (Pan)
PIK3CA V344M Akt1 Inhibitor
PIK3CA E726K mTORC2 Inhibitor
PIK3CA H1047P mTOR Inhibitor
PIK3CA D549N mTORC1 Inhibitor
PIK3CA R93W mTOR Inhibitor
PIK3CA G106V Akt2 Inhibitor
PIK3CA V955G mTOR Inhibitor
PIK3CA H1047Y Akt1 Inhibitor
PIK3CA G364R mTORC1 Inhibitor
PIK3CA C378Y mTORC1 Inhibitor
PIK3CA K111E Akt2 Inhibitor
PIK3CA E469delinsDK Akt1 Inhibitor
PIK3CA E39K Akt Inhibitor (Pan)
PIK3CA M1043L PIK3CA inhibitor
PIK3CA Q546R Akt Inhibitor (Pan)
PIK3CA K944N PI3K Inhibitor (Pan)
PIK3CA D549N Akt2 Inhibitor
PIK3CA Q546E mTORC1 Inhibitor
PIK3CA N1068fs mTOR Inhibitor
PIK3CA P447_L455del Akt2 Inhibitor
PIK3CA D350G Akt1 Inhibitor
PIK3CA M1043V mTOR Inhibitor
PIK3CA H1047L Akt Inhibitor (Pan)
PIK3CA T1025S mTOR Inhibitor
PIK3CA C378Y mTORC2 Inhibitor
PIK3CA S629C Akt Inhibitor (Pan)
PIK3CA M1043I PI3K Inhibitor (Pan)
PIK3CA G364R Akt Inhibitor (Pan)
PIK3CA G451R mTORC1 Inhibitor
PIK3CA E365V Akt1 Inhibitor
PIK3CA E545D mTOR Inhibitor
PIK3CA E545G PIK3CA inhibitor
PIK3CA E545A mTORC2 Inhibitor
PIK3CA H1047Q Akt2 Inhibitor
PIK3CA V344G Akt Inhibitor (Pan)
PIK3CA H450_P458del Akt Inhibitor (Pan)
PIK3CA P447_L455del mTORC2 Inhibitor
PIK3CA M1043L mTORC2 Inhibitor
PIK3CA H1047K PIK3CA inhibitor
PIK3CA K966E PIK3CA inhibitor
PIK3CA E545D Akt Inhibitor (Pan)
PIK3CA R93W PIK3CA inhibitor
PIK3CA G106V mTORC2 Inhibitor
PIK3CA E365K mTORC1 Inhibitor
PIK3CA H1047L Akt1 Inhibitor
PIK3CA R38H mTORC1 Inhibitor
PIK3CA N345K Akt1 Inhibitor
PIK3CA E103_G106delinsD Akt Inhibitor (Pan)
PIK3CA K966E mTOR Inhibitor
PIK3CA G106R Akt Inhibitor (Pan)
PIK3CA H1047Y Akt2 Inhibitor
PIK3CA S629C PI3K Inhibitor (Pan)
PIK3CA P366R PI3K Inhibitor (Pan)
PIK3CA V344G mTOR Inhibitor
PIK3CA G364R PI3K Inhibitor (Pan)
PIK3CA R115L Akt2 Inhibitor
PIK3CA C378Y Akt2 Inhibitor
PIK3CA E453Q PI3K Inhibitor (Pan)
PIK3CA C604R PI3K Inhibitor (Pan)
PIK3CA G118D Akt2 Inhibitor
PIK3CA E542K PIK3CA inhibitor
PIK3CA D350N mTOR Inhibitor
PIK3CA R115L Akt Inhibitor (Pan)
PIK3CA E542A mTORC2 Inhibitor
PIK3CA N1068Kfs*5 PIK3CA inhibitor
PIK3CA E1037K Akt Inhibitor (Pan)
PIK3CA P539R mTORC1 Inhibitor
PIK3CA Y1021C PI3K Inhibitor (Pan)
PIK3CA Q546R PI3K Inhibitor (Pan)
PIK3CA C901F Akt2 Inhibitor
PIK3CA G451R Akt1 Inhibitor
PIK3CA E39K PI3K Inhibitor (Pan)
PIK3CA R108C mTOR Inhibitor
PIK3CA H1047P PI3K Inhibitor (Pan)
PIK3CA P449T PIK3CA inhibitor
PIK3CA E103_P104del Akt Inhibitor (Pan)
PIK3CA Q546L mTOR Inhibitor
PIK3CA G106_R108del mTORC1 Inhibitor
PIK3CA E545V Akt1 Inhibitor
PIK3CA V344M PI3K Inhibitor (Pan)
PIK3CA P124L Akt2 Inhibitor
PIK3CA R38C PIK3CA inhibitor
PIK3CA Q546L PI3K Inhibitor (Pan)
PIK3CA P471L Akt1 Inhibitor
PIK3CA E542V mTORC2 Inhibitor
PIK3CA E453A Akt1 Inhibitor
PIK3CA G451R PI3K Inhibitor (Pan)
PIK3CA E545X Akt2 Inhibitor
PIK3CA H450_P458del mTORC1 Inhibitor
PIK3CA E545A PIK3CA inhibitor
PIK3CA E545G Akt Inhibitor (Pan)
PIK3CA I910V mTOR Inhibitor
PIK3CA F930S mTOR Inhibitor
PIK3CA N1068Kfs*5 Akt Inhibitor (Pan)
PIK3CA E545K Akt Inhibitor (Pan)
PIK3CA E103_G106delinsD PI3K Inhibitor (Pan)
PIK3CA T1025N mTORC2 Inhibitor
PIK3CA N1044K mTORC1 Inhibitor
PIK3CA E542V Akt Inhibitor (Pan)
PIK3CA F930S Akt Inhibitor (Pan)
PIK3CA G1007R Akt2 Inhibitor
PIK3CA H1047Q Akt1 Inhibitor
PIK3CA P449T mTORC2 Inhibitor
PIK3CA H1047K Akt2 Inhibitor
PIK3CA C604R mTORC1 Inhibitor
PIK3CA P449_N457del mTORC1 Inhibitor
PIK3CA M1043L mTOR Inhibitor
PIK3CA V955G mTORC1 Inhibitor
PIK3CA E103_G106delinsD PIK3CA inhibitor
PIK3CA K111E mTOR Inhibitor
PIK3CA Q546K mTOR Inhibitor
PIK3CA T1025N Akt Inhibitor (Pan)
PIK3CA N1068Kfs*5 mTORC2 Inhibitor
PIK3CA V955G PI3K Inhibitor (Pan)
PIK3CA E545X Akt1 Inhibitor
PIK3CA E545K mTORC1 Inhibitor
PIK3CA E542A Akt Inhibitor (Pan)
PIK3CA P449T PI3K Inhibitor (Pan)
PIK3CA N1044K Akt2 Inhibitor
PIK3CA G118D mTORC1 Inhibitor
PIK3CA E365K Akt1 Inhibitor
PIK3CA G364R Akt2 Inhibitor
PIK3CA T1025A mTORC1 Inhibitor
PIK3CA P449_N457del mTORC2 Inhibitor
PIK3CA I112N Akt2 Inhibitor
PIK3CA E365V Akt2 Inhibitor
PIK3CA H1047R Akt Inhibitor (Pan)
PIK3CA E103_P104del PIK3CA inhibitor
PIK3CA E469delinsDK mTORC1 Inhibitor
PIK3CA E545X mTOR Inhibitor
PIK3CA E545V Akt2 Inhibitor
PIK3CA N1044K mTORC2 Inhibitor
PIK3CA M1043I mTORC2 Inhibitor
PIK3CA V955I Akt1 Inhibitor
PIK3CA M1043V PIK3CA inhibitor
PIK3CA T1025A mTOR Inhibitor
PIK3CA R93W Akt2 Inhibitor
PIK3CA L938* mTORC2 Inhibitor
PIK3CA Q546E mTORC2 Inhibitor
PIK3CA Q546E PI3K Inhibitor (Pan)
PIK3CA E542G PIK3CA inhibitor
PIK3CA E453A mTOR Inhibitor
PIK3CA E109_I112delinsD mTORC2 Inhibitor
PIK3CA E453Q PIK3CA inhibitor
PIK3CA L938* mTORC1 Inhibitor
PIK3CA E542A PIK3CA inhibitor
PIK3CA R88Q mTORC1 Inhibitor
PIK3CA E109_I112delinsD Akt2 Inhibitor
PIK3CA I910V Akt Inhibitor (Pan)
PIK3CA E545X PI3K Inhibitor (Pan)
PIK3CA H1047Q mTORC2 Inhibitor
PIK3CA R93P mTOR Inhibitor
PIK3CA R108H mTORC2 Inhibitor
PIK3CA V952A mTORC1 Inhibitor
PIK3CA G106R mTORC1 Inhibitor
PIK3CA T1025A Akt1 Inhibitor
PIK3CA T1025S Akt2 Inhibitor
PIK3CA E453A PI3K Inhibitor (Pan)
PIK3CA R108C Akt1 Inhibitor
PIK3CA E1037K mTOR Inhibitor
PIK3CA H1047X Akt2 Inhibitor
PIK3CA C420R Akt1 Inhibitor
PIK3CA E542A PI3K Inhibitor (Pan)
PIK3CA F930S mTORC1 Inhibitor
PIK3CA E545D mTORC2 Inhibitor
PIK3CA R108H PI3K Inhibitor (Pan)
PIK3CA L938* PI3K Inhibitor (Pan)
PIK3CA Q546P mTOR Inhibitor
PIK3CA K944N Akt Inhibitor (Pan)
PIK3CA D939G mTOR Inhibitor
PIK3CA Q546K Akt Inhibitor (Pan)
PIK3CA T1025A mTORC2 Inhibitor
PIK3CA L938* mTOR Inhibitor
PIK3CA P449T Akt1 Inhibitor
PIK3CA V952A PIK3CA inhibitor
PIK3CA E453Q mTORC2 Inhibitor
PIK3CA G106R Akt2 Inhibitor
PIK3CA P449_L455del Akt Inhibitor (Pan)
PIK3CA Q546R Akt2 Inhibitor
PIK3CA H1047Y mTORC2 Inhibitor
PIK3CA G1049R PI3K Inhibitor (Pan)
PIK3CA E103_P104del mTOR Inhibitor
PIK3CA E545A Akt2 Inhibitor
PIK3CA T1025N PI3K Inhibitor (Pan)
PIK3CA H450_P458del mTORC2 Inhibitor
PIK3CA C378R Akt1 Inhibitor
PIK3CA R93P PI3K Inhibitor (Pan)
PIK3CA P539R mTORC2 Inhibitor
PIK3CA E542V mTOR Inhibitor
PIK3CA E453K PIK3CA inhibitor
PIK3CA K111E Akt Inhibitor (Pan)
PIK3CA P539R PIK3CA inhibitor
PIK3CA G106_R108del Akt Inhibitor (Pan)
PIK3CA M1004I mTORC1 Inhibitor
PIK3CA H1047K PI3K Inhibitor (Pan)
PIK3CA K111N mTORC1 Inhibitor
PIK3CA K944N mTOR Inhibitor
PIK3CA G106R Akt1 Inhibitor
PIK3CA E1037K mTORC1 Inhibitor
PIK3CA E545V mTOR Inhibitor
PIK3CA P449_L455del Akt1 Inhibitor
PIK3CA H450_P458del Akt2 Inhibitor
PIK3CA G106V PIK3CA inhibitor
PIK3CA S629C PIK3CA inhibitor
PIK3CA C378Y Akt Inhibitor (Pan)
PIK3CA P449_N457del PI3K Inhibitor (Pan)
PIK3CA I910V Akt2 Inhibitor
PIK3CA C420R mTORC2 Inhibitor
PIK3CA R93W mTORC2 Inhibitor
PIK3CA E542K Akt Inhibitor (Pan)
PIK3CA P124L mTOR Inhibitor
PIK3CA R115L PI3K Inhibitor (Pan)
PIK3CA R108H mTOR Inhibitor
PIK3CA V105_R108del mTORC1 Inhibitor
PIK3CA E1037K mTORC2 Inhibitor
PIK3CA K111E mTORC1 Inhibitor
PIK3CA D939G PI3K Inhibitor (Pan)
PIK3CA N345K mTORC1 Inhibitor
PIK3CA V955I Akt Inhibitor (Pan)
PIK3CA G451V Akt1 Inhibitor
PIK3CA D1029Y mTOR Inhibitor
PIK3CA P449_N457del PIK3CA inhibitor
PIK3CA N345K mTORC2 Inhibitor
PIK3CA V955I PIK3CA inhibitor
PIK3CA N345K PIK3CA inhibitor
PIK3CA D350N mTORC2 Inhibitor
PIK3CA R93W PI3K Inhibitor (Pan)
PIK3CA E545Q mTORC1 Inhibitor
PIK3CA H1047L PIK3CA inhibitor
PIK3CA G1049R Akt Inhibitor (Pan)
PIK3CA E726K PI3K Inhibitor (Pan)
PIK3CA E365V mTOR Inhibitor
PIK3CA G1007R Akt1 Inhibitor
PIK3CA E542K mTORC2 Inhibitor
PIK3CA G364R mTORC2 Inhibitor
PIK3CA D350G mTOR Inhibitor
PIK3CA M1043I Akt1 Inhibitor
PIK3CA E365K mTORC2 Inhibitor
PIK3CA E39K mTOR Inhibitor
PIK3CA E542G mTORC1 Inhibitor
PIK3CA act mut Akt1 Inhibitor
PIK3CA E103_G106delinsD Akt1 Inhibitor
PIK3CA M1043I PIK3CA inhibitor
PIK3CA P449_N457del mTOR Inhibitor
PIK3CA V955G Akt Inhibitor (Pan)
PIK3CA Y1021C Akt2 Inhibitor
PIK3CA E545V Akt Inhibitor (Pan)
PIK3CA H1047R Akt1 Inhibitor
PIK3CA N345I mTORC1 Inhibitor
PIK3CA R38C mTORC1 Inhibitor
PIK3CA Q546E mTOR Inhibitor
PIK3CA V344G PIK3CA inhibitor
PIK3CA E545V mTORC2 Inhibitor
PIK3CA E365K Akt Inhibitor (Pan)
PIK3CA P471L Akt2 Inhibitor
PIK3CA E39K Akt1 Inhibitor
PIK3CA P539R mTOR Inhibitor
PIK3CA P449_L455del Akt2 Inhibitor
PIK3CA P471L PI3K Inhibitor (Pan)
PIK3CA V952A PI3K Inhibitor (Pan)
PIK3CA R93P mTORC2 Inhibitor
PIK3CA C604R mTORC2 Inhibitor
PIK3CA G118D mTOR Inhibitor
PIK3CA H1047P Akt1 Inhibitor
PIK3CA D350G mTORC1 Inhibitor
PIK3CA Q546E Akt1 Inhibitor
PIK3CA G106V mTORC1 Inhibitor
PIK3CA T1025N Akt1 Inhibitor
PIK3CA G451R PIK3CA inhibitor
PIK3CA R38H PIK3CA inhibitor
PIK3CA Q546P PI3K Inhibitor (Pan)
PIK3CA N345T Akt2 Inhibitor
PIK3CA E545Q Akt2 Inhibitor
PIK3CA I910V mTORC1 Inhibitor
PIK3CA Q546P mTORC1 Inhibitor
PIK3CA G106V mTOR Inhibitor
PIK3CA R88Q mTOR Inhibitor
PIK3CA C901F Akt1 Inhibitor
PIK3CA R108H Akt1 Inhibitor
PIK3CA E545K PI3K Inhibitor (Pan)
PIK3CA E545G Akt2 Inhibitor
PIK3CA H1047P Akt2 Inhibitor
PIK3CA Y1021C mTORC2 Inhibitor
PIK3CA N345T Akt Inhibitor (Pan)
PIK3CA K966E PI3K Inhibitor (Pan)
PIK3CA G451R mTORC2 Inhibitor
PIK3CA H1047Q Akt Inhibitor (Pan)
PIK3CA H1047Y mTORC1 Inhibitor
PIK3CA P471L mTORC2 Inhibitor
PIK3CA E545G PI3K Inhibitor (Pan)
PIK3CA S629C Akt1 Inhibitor
PIK3CA P539R Akt2 Inhibitor
PIK3CA E469delinsDK Akt2 Inhibitor
PIK3CA E545A PI3K Inhibitor (Pan)
PIK3CA N345K mTOR Inhibitor
PIK3CA P366R mTORC2 Inhibitor
PIK3CA E365V PI3K Inhibitor (Pan)
PIK3CA R38C Akt Inhibitor (Pan)
PIK3CA Q546R Akt1 Inhibitor
PIK3CA H1047P PIK3CA inhibitor
PIK3CA E110del Akt Inhibitor (Pan)
PIK3CA K944N Akt1 Inhibitor
PIK3CA E545X Akt Inhibitor (Pan)
PIK3CA G364R PIK3CA inhibitor
PIK3CA M1004I Akt2 Inhibitor
PIK3CA P471L PIK3CA inhibitor
PIK3CA P124L PI3K Inhibitor (Pan)
PIK3CA N345I PIK3CA inhibitor
PIK3CA G451V mTORC1 Inhibitor
PIK3CA act mut Akt2 Inhibitor
PIK3CA E453A PIK3CA inhibitor
PIK3CA D939G mTORC2 Inhibitor
PIK3CA E545D mTORC1 Inhibitor
PIK3CA R38H Akt2 Inhibitor
PIK3CA P471L mTOR Inhibitor
PIK3CA H450_P458del Akt1 Inhibitor
PIK3CA K966E Akt2 Inhibitor
PIK3CA E726K mTOR Inhibitor
PIK3CA V344M mTORC1 Inhibitor
PIK3CA D350G Akt2 Inhibitor
PIK3CA Q546L Akt Inhibitor (Pan)
PIK3CA G106_R108del PI3K Inhibitor (Pan)
PIK3CA H1047L mTORC1 Inhibitor
PIK3CA E365K Akt2 Inhibitor
PIK3CA M1043V Akt Inhibitor (Pan)
PIK3CA E103_P104del Akt1 Inhibitor
PIK3CA E365K PIK3CA inhibitor
PIK3CA E469delinsDK PI3K Inhibitor (Pan)
PIK3CA T1025S PIK3CA inhibitor
PIK3CA V105_R108del mTOR Inhibitor
PIK3CA G451R Akt Inhibitor (Pan)
PIK3CA K111N mTOR Inhibitor
PIK3CA E365V mTORC2 Inhibitor
PIK3CA M1004I PIK3CA inhibitor
PIK3CA E103_G106delinsD mTORC1 Inhibitor
PIK3CA G1049R PIK3CA inhibitor
PIK3CA E542V PI3K Inhibitor (Pan)
PIK3CA E103_P104del mTORC1 Inhibitor
PIK3CA K966E mTORC2 Inhibitor
PIK3CA G451R Akt2 Inhibitor
PIK3CA Y1021C PIK3CA inhibitor
PIK3CA E365V PIK3CA inhibitor
PIK3CA R93W mTORC1 Inhibitor
PIK3CA R108H PIK3CA inhibitor
PIK3CA Q546R mTORC1 Inhibitor
PIK3CA P539R Akt1 Inhibitor
PIK3CA act mut Akt Inhibitor (Pan)
PIK3CA H1047L mTORC2 Inhibitor
PIK3CA C971R mTORC1 Inhibitor
PIK3CA I112N PIK3CA inhibitor
PIK3CA V955G Akt1 Inhibitor
PIK3CA P447_L455del PI3K Inhibitor (Pan)
PIK3CA P366R mTORC1 Inhibitor
PIK3CA E1037K PI3K Inhibitor (Pan)
PIK3CA R115L Akt1 Inhibitor
PIK3CA E103_P104del PI3K Inhibitor (Pan)
PIK3CA C604R Akt2 Inhibitor
PIK3CA G1049R Akt1 Inhibitor
PIK3CA D549N mTOR Inhibitor
PIK3CA D939G Akt2 Inhibitor
PIK3CA E453K Akt1 Inhibitor
PIK3CA N1044K mTOR Inhibitor
PIK3CA V952A Akt2 Inhibitor
PIK3CA K111N PIK3CA inhibitor
PIK3CA P449T Akt2 Inhibitor
PIK3CA M1004I Akt1 Inhibitor
PIK3CA T1025N mTOR Inhibitor
PIK3CA E545K mTOR Inhibitor
PIK3CA V105_R108del Akt1 Inhibitor
PIK3CA M1004I Akt Inhibitor (Pan)
PIK3CA P366R PIK3CA inhibitor
PIK3CA E109_I112delinsD Akt1 Inhibitor
PIK3CA E542V Akt1 Inhibitor
PIK3CA I112N Akt1 Inhibitor
PIK3CA E545K Akt1 Inhibitor
PIK3CA E542V mTORC1 Inhibitor
PIK3CA G106_R108del mTOR Inhibitor
PIK3CA P366R mTOR Inhibitor
PIK3CA H1047Y Akt Inhibitor (Pan)
PIK3CA L938* Akt Inhibitor (Pan)
PIK3CA D939G Akt1 Inhibitor
PIK3CA R38H Akt1 Inhibitor
PIK3CA I910V mTORC2 Inhibitor
PIK3CA Q546P mTORC2 Inhibitor
PIK3CA R88Q Akt2 Inhibitor
PIK3CA D549N Akt Inhibitor (Pan)
PIK3CA Q546K Akt2 Inhibitor
PIK3CA C420R PIK3CA inhibitor
PIK3CA V344G Akt1 Inhibitor
PIK3CA R115L mTOR Inhibitor
PIK3CA V955I mTOR Inhibitor
PIK3CA D549N mTORC2 Inhibitor
PIK3CA G451V mTOR Inhibitor
PIK3CA E545V PI3K Inhibitor (Pan)
PIK3CA N345T PIK3CA inhibitor
PIK3CA H1047Y PI3K Inhibitor (Pan)
PIK3CA M1043L mTORC1 Inhibitor
PIK3CA G106V Akt1 Inhibitor
PIK3CA I112N Akt Inhibitor (Pan)
PIK3CA K111N Akt1 Inhibitor
PIK3CA M1004I mTORC2 Inhibitor
PIK3CA P104L PIK3CA inhibitor
PIK3CA K111N Akt2 Inhibitor
PIK3CA V955I mTORC1 Inhibitor
PIK3CA M1043L PI3K Inhibitor (Pan)
PIK3CA T1025S Akt1 Inhibitor
PIK3CA E110del PIK3CA inhibitor
PIK3CA G1007R Akt Inhibitor (Pan)
PIK3CA C378R PIK3CA inhibitor
PIK3CA act mut PIK3CA inhibitor
PIK3CA Q546L Akt1 Inhibitor
PIK3CA R93P Akt Inhibitor (Pan)
PIK3CA E103_P104del mTORC2 Inhibitor
PIK3CA Q546E Akt Inhibitor (Pan)
PIK3CA C901F mTORC2 Inhibitor
PIK3CA C378Y mTOR Inhibitor
PIK3CA M1043V Akt1 Inhibitor
PIK3CA N345I Akt Inhibitor (Pan)
PIK3CA K111E PIK3CA inhibitor
PIK3CA N1068fs Akt2 Inhibitor
PIK3CA G1049R mTORC1 Inhibitor
PIK3CA T1025N mTORC1 Inhibitor
PIK3CA E545A mTOR Inhibitor
PIK3CA R115L mTORC1 Inhibitor
PIK3CA F930S Akt2 Inhibitor
PIK3CA C420R Akt2 Inhibitor
PIK3CA H1047X mTORC1 Inhibitor
PIK3CA D350G PIK3CA inhibitor
PIK3CA Q546L mTORC1 Inhibitor
PIK3CA E110del mTOR Inhibitor
PIK3CA Q546E PIK3CA inhibitor
PIK3CA F930S PIK3CA inhibitor
PIK3CA V344G PI3K Inhibitor (Pan)
PIK3CA G451R mTOR Inhibitor
PIK3CA E453A mTORC1 Inhibitor
PIK3CA Q546K PIK3CA inhibitor
PIK3CA N1044K PIK3CA inhibitor
PIK3CA N345I mTOR Inhibitor
PIK3CA E453A mTORC2 Inhibitor
PIK3CA E110del mTORC2 Inhibitor
PIK3CA R88Q PIK3CA inhibitor
PIK3CA H1047K mTOR Inhibitor
PIK3CA R38H PI3K Inhibitor (Pan)
PIK3CA P104L mTORC1 Inhibitor
PIK3CA V952A mTORC2 Inhibitor
PIK3CA P539R Akt Inhibitor (Pan)
PIK3CA D549N Akt1 Inhibitor
PIK3CA E545D PI3K Inhibitor (Pan)
PIK3CA E469delinsDK Akt Inhibitor (Pan)
PIK3CA Q546K Akt1 Inhibitor
PIK3CA G1007R PI3K Inhibitor (Pan)
PIK3CA E1037K PIK3CA inhibitor
PIK3CA E453Q Akt1 Inhibitor
PIK3CA T1025A PIK3CA inhibitor
PIK3CA M1043L Akt Inhibitor (Pan)
PIK3CA G106_R108del mTORC2 Inhibitor
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
PIK3CA D1045N missense unknown PIK3CA D1045N lies within the PI3K/PI4K domain of the Pik3ca protein (UniProt.org). D1045N has been identified in the scientific literature (PMID: 25624430, PMID: 26850916, PMID: 23248156), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Feb 2020).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References