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Ref Type Journal Article
PMID (22932669)
Authors Sangai T, Akcakanat A, Chen H, Tarco E, Wu Y, Do KA, Miller TW, Arteaga CL, Mills GB, Gonzalez-Angulo AM, Meric-Bernstam F
Title Biomarkers of response to Akt inhibitor MK-2206 in breast cancer.
Journal Clinical cancer research : an official journal of the American Association for Cancer Research
Vol 18
Issue 20
Date 2012 Oct 15
URL
Abstract Text We tested the hypothesis that allosteric Akt inhibitor MK-2206 inhibits tumor growth, and that PTEN/PIK3CA mutations confer MK-2206 sensitivity.MK-2206 effects on cell signaling were assessed in vitro and in vivo. Its antitumor efficacy was assessed in vitro in a panel of cancer cell lines with differing PIK3CA and PTEN status. Its in vivo efficacy was tested as a single agent and in combination with paclitaxel.MK-2206 inhibited Akt signaling and cell-cycle progression, and increased apoptosis in a dose-dependent manner in breast cancer cell lines. Cell lines with PTEN or PIK3CA mutations were significantly more sensitive to MK-2206; however, several lines with PTEN/PIK3CA mutations were MK-2206 resistant. siRNA knockdown of PTEN in breast cancer cells increased Akt phosphorylation concordant with increased MK-2206 sensitivity. Stable transfection of PIK3CA E545K or H1047R mutant plasmids into normal-like MCF10A breast cells enhanced MK-2206 sensitivity. Cell lines that were less sensitive to MK-2206 had lower ratios of Akt1/Akt2 and had less growth inhibition with Akt siRNA knockdown. In PTEN-mutant ZR75-1 breast cancer xenografts, MK-2206 treatment inhibited Akt signaling, cell proliferation, and tumor growth. In vitro, MK-2206 showed a synergistic interaction with paclitaxel in MK-2206-sensitive cell lines, and this combination had significantly greater antitumor efficacy than either agent alone in vivo.MK-2206 has antitumor activity alone and in combination with chemotherapy. This activity may be greater in tumors with PTEN loss or PIK3CA mutation, providing a strategy for patient enrichment in clinical trials.

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Molecular Profile Treatment Approach
PTEN G129* Akt Inhibitor (Pan)
PTEN P96del Akt Inhibitor (Pan)
PTEN K128T Akt Inhibitor (Pan)
PTEN K62R Akt Inhibitor (Pan)
PTEN S170N Akt Inhibitor (Pan)
PTEN Y176del Akt Inhibitor (Pan)
PTEN W111fs Akt Inhibitor (Pan)
PTEN K260fs Akt Inhibitor (Pan)
PTEN E18* Akt Inhibitor (Pan)
PTEN H61D Akt Inhibitor (Pan)
PTEN C124W Akt Inhibitor (Pan)
PTEN L152P Akt Inhibitor (Pan)
PTEN Y155H Akt Inhibitor (Pan)
PTEN E150* Akt Inhibitor (Pan)
PTEN V166E Akt Inhibitor (Pan)
PTEN G127E Akt Inhibitor (Pan)
PTEN R15I Akt Inhibitor (Pan)
PTEN G251C Akt Inhibitor (Pan)
PTEN T167A Akt Inhibitor (Pan)
PTEN D324del Akt Inhibitor (Pan)
PTEN H123Q Akt Inhibitor (Pan)
PTEN F241S Akt Inhibitor (Pan)
PTEN F90S Akt Inhibitor (Pan)
PTEN G165E Akt Inhibitor (Pan)
PTEN Y65S Akt Inhibitor (Pan)
PTEN L325R Akt Inhibitor (Pan)
PTEN A121E Akt Inhibitor (Pan)
PTEN S59P Akt Inhibitor (Pan)
PTEN G127N Akt Inhibitor (Pan)
PTEN A121P Akt Inhibitor (Pan)
PTEN G127R Akt Inhibitor (Pan)
PTEN C250fs Akt Inhibitor (Pan)
PTEN D24del Akt Inhibitor (Pan)
PTEN F257L Akt Inhibitor (Pan)
PTEN L247Sfs*6 Akt Inhibitor (Pan)
PTEN M264T Akt Inhibitor (Pan)
PTEN I33N Akt Inhibitor (Pan)
PTEN K125E Akt Inhibitor (Pan)
PTEN L23V Akt Inhibitor (Pan)
PTEN Y176* Akt Inhibitor (Pan)
PTEN Q87* Akt Inhibitor (Pan)
PTEN N276T Akt Inhibitor (Pan)
PTEN K128_R130del Akt Inhibitor (Pan)
PTEN N12T Akt Inhibitor (Pan)
PTEN R189* Akt Inhibitor (Pan)
PTEN K128Q Akt Inhibitor (Pan)
PTEN P38H Akt Inhibitor (Pan)
PTEN T348I Akt Inhibitor (Pan)
PTEN H61K Akt Inhibitor (Pan)
PTEN H93Q Akt Inhibitor (Pan)
PTEN G44D Akt Inhibitor (Pan)
PTEN P95L Akt Inhibitor (Pan)
PTEN R159L Akt Inhibitor (Pan)
PTEN V158fs Akt Inhibitor (Pan)
PTEN R74Dfs*25 Akt Inhibitor (Pan)
PTEN G132V Akt Inhibitor (Pan)
PTEN E242* Akt Inhibitor (Pan)
PTEN T131P Akt Inhibitor (Pan)
PTEN F56S Akt Inhibitor (Pan)
PTEN K221* Akt Inhibitor (Pan)
PTEN E299* Akt Inhibitor (Pan)
PTEN G20E Akt Inhibitor (Pan)
PTEN G132C Akt Inhibitor (Pan)
PTEN R130* Akt Inhibitor (Pan)
PTEN I122F Akt Inhibitor (Pan)
PTEN I28N Akt Inhibitor (Pan)
PTEN A126S Akt Inhibitor (Pan)
PTEN F241fs Akt Inhibitor (Pan)
PTEN K66fs Akt Inhibitor (Pan)
PTEN D252V Akt Inhibitor (Pan)
PTEN K322E Akt Inhibitor (Pan)
PTEN D92E Akt Inhibitor (Pan)
PTEN L42P Akt Inhibitor (Pan)
PTEN C211W Akt Inhibitor (Pan)
PTEN T319fs Akt Inhibitor (Pan)
PTEN P339L Akt Inhibitor (Pan)
PTEN C105G Akt Inhibitor (Pan)
PTEN N63fs Akt Inhibitor (Pan)
PTEN G36E Akt Inhibitor (Pan)
PTEN L108P Akt Inhibitor (Pan)
PTEN E73K Akt Inhibitor (Pan)
PTEN G36R Akt Inhibitor (Pan)
PTEN D162Y Akt Inhibitor (Pan)
PTEN S227F Akt Inhibitor (Pan)
PTEN Q110* Akt Inhibitor (Pan)
PTEN I122S Akt Inhibitor (Pan)
PTEN M134T Akt Inhibitor (Pan)
PTEN L70fs Akt Inhibitor (Pan)
PTEN W111S Akt Inhibitor (Pan)
PTEN M134del Akt Inhibitor (Pan)
PTEN D326N Akt Inhibitor (Pan)
PTEN P95Q Akt Inhibitor (Pan)
PTEN R14G Akt Inhibitor (Pan)
PTEN D52del Akt Inhibitor (Pan)
PTEN V119del Akt Inhibitor (Pan)
PTEN G282* Akt Inhibitor (Pan)
PTEN I122L Akt Inhibitor (Pan)
PTEN K267fs Akt Inhibitor (Pan)
PTEN D326* Akt Inhibitor (Pan)
PTEN S302Afs*5 Akt Inhibitor (Pan)
PTEN G132S Akt Inhibitor (Pan)
PTEN K267* Akt Inhibitor (Pan)
PTEN R130S Akt Inhibitor (Pan)
PTEN Y177S Akt Inhibitor (Pan)
PTEN D252G Akt Inhibitor (Pan)
PTEN F337fs Akt Inhibitor (Pan)
PTEN M198R Akt Inhibitor (Pan)
PTEN D92A Akt Inhibitor (Pan)
PTEN T131N Akt Inhibitor (Pan)
PTEN G165V Akt Inhibitor (Pan)
PTEN K263* Akt Inhibitor (Pan)
PTEN P246fs Akt Inhibitor (Pan)
PTEN W274fs Akt Inhibitor (Pan)
PTEN C136W Akt Inhibitor (Pan)
PTEN R130A Akt Inhibitor (Pan)
PTEN D24N Akt Inhibitor (Pan)
PTEN P38F Akt Inhibitor (Pan)
PTEN T160del Akt Inhibitor (Pan)
PTEN C105Y Akt Inhibitor (Pan)
PTEN Q171R Akt Inhibitor (Pan)
PTEN I101N Akt Inhibitor (Pan)
PTEN L70P Akt Inhibitor (Pan)
PTEN L42R Akt Inhibitor (Pan)
PTEN T131I Akt Inhibitor (Pan)
PTEN C105W Akt Inhibitor (Pan)
PTEN Q17del Akt Inhibitor (Pan)
PTEN T160I Akt Inhibitor (Pan)
PTEN T319del Akt Inhibitor (Pan)
PTEN N94I Akt Inhibitor (Pan)
PTEN Y88* Akt Inhibitor (Pan)
PTEN L140* Akt Inhibitor (Pan)
PTEN E242fs Akt Inhibitor (Pan)
PTEN L108R Akt Inhibitor (Pan)
PTEN K163fs Akt Inhibitor (Pan)
PTEN A126G Akt Inhibitor (Pan)
PTEN T232A Akt Inhibitor (Pan)
PTEN P95S Akt Inhibitor (Pan)
PTEN Q171K Akt Inhibitor (Pan)
PTEN D116fs Akt Inhibitor (Pan)
PTEN L193P Akt Inhibitor (Pan)
PTEN H93L Akt Inhibitor (Pan)
PTEN C136R Akt Inhibitor (Pan)
PTEN K125N Akt Inhibitor (Pan)
PTEN G251D Akt Inhibitor (Pan)
PTEN Y88D Akt Inhibitor (Pan)
PTEN K125* Akt Inhibitor (Pan)
PTEN Y177* Akt Inhibitor (Pan)
PTEN K330* Akt Inhibitor (Pan)
PTEN L70R Akt Inhibitor (Pan)
PTEN C71W Akt Inhibitor (Pan)
PTEN D162del Akt Inhibitor (Pan)
PTEN E106* Akt Inhibitor (Pan)
PTEN V317fs Akt Inhibitor (Pan)
PTEN R233* Akt Inhibitor (Pan)
PTEN V249E Akt Inhibitor (Pan)
PTEN N276S Akt Inhibitor (Pan)
PTEN C218* Akt Inhibitor (Pan)
PTEN V217fs Akt Inhibitor (Pan)
PTEN C136F Akt Inhibitor (Pan)
PTEN Y27S Akt Inhibitor (Pan)
PTEN L112R Akt Inhibitor (Pan)
PTEN G293* Akt Inhibitor (Pan)
PTEN L182fs Akt Inhibitor (Pan)
PTEN F56fs Akt Inhibitor (Pan)
PTEN E114* Akt Inhibitor (Pan)
PTEN E201* Akt Inhibitor (Pan)
PTEN Y68H Akt Inhibitor (Pan)
PTEN P38R Akt Inhibitor (Pan)
PTEN E285* Akt Inhibitor (Pan)
PTEN N340fs Akt Inhibitor (Pan)
PTEN T167P Akt Inhibitor (Pan)
PTEN C124F Akt Inhibitor (Pan)
PTEN R55fs Akt Inhibitor (Pan)
PTEN T131fs Akt Inhibitor (Pan)
PTEN N212Kfs*10 Akt Inhibitor (Pan)
PTEN Y46D Akt Inhibitor (Pan)
PTEN L182P Akt Inhibitor (Pan)
PTEN S59* Akt Inhibitor (Pan)
PTEN K6E Akt Inhibitor (Pan)
PTEN P248fs Akt Inhibitor (Pan)
PTEN I122N Akt Inhibitor (Pan)
PTEN S10N Akt Inhibitor (Pan)
PTEN G129D Akt Inhibitor (Pan)
PTEN Q219* Akt Inhibitor (Pan)
PTEN H93Y Akt Inhibitor (Pan)
PTEN L57S Akt Inhibitor (Pan)
PTEN Q298* Akt Inhibitor (Pan)
PTEN Y68fs Akt Inhibitor (Pan)
PTEN I135R Akt Inhibitor (Pan)
PTEN G129E Akt Inhibitor (Pan)
PTEN Q17Kfs*7 Akt Inhibitor (Pan)
PTEN E291* Akt Inhibitor (Pan)
PTEN S229* Akt Inhibitor (Pan)
PTEN K125M Akt Inhibitor (Pan)
PTEN R159I Akt Inhibitor (Pan)
PTEN C83* Akt Inhibitor (Pan)
PTEN L181P Akt Inhibitor (Pan)
PTEN M198K Akt Inhibitor (Pan)
PTEN N48I Akt Inhibitor (Pan)
PTEN I33del Akt Inhibitor (Pan)
PTEN S170R Akt Inhibitor (Pan)
PTEN del Akt Inhibitor (Pan)
PTEN L70V Akt Inhibitor (Pan)
PTEN K266* Akt Inhibitor (Pan)
PTEN E314* Akt Inhibitor (Pan)
PTEN Y76* Akt Inhibitor (Pan)
PTEN I8Dfs*3 Akt Inhibitor (Pan)
PTEN Y177D Akt Inhibitor (Pan)
PTEN N292fs Akt Inhibitor (Pan)
PTEN L318fs Akt Inhibitor (Pan)
PTEN K342* Akt Inhibitor (Pan)
PTEN G129V Akt Inhibitor (Pan)
PTEN Y174N Akt Inhibitor (Pan)
PTEN inact mut Akt Inhibitor (Pan)
PTEN Y68C Akt Inhibitor (Pan)
PTEN G230* Akt Inhibitor (Pan)
PTEN I67K Akt Inhibitor (Pan)
PTEN Q245P Akt Inhibitor (Pan)
PTEN K60fs Akt Inhibitor (Pan)
PTEN G156W Akt Inhibitor (Pan)
PTEN L140F Akt Inhibitor (Pan)
PTEN R130K Akt Inhibitor (Pan)
PTEN E43* Akt Inhibitor (Pan)
PTEN D109fs Akt Inhibitor (Pan)
PTEN V53E Akt Inhibitor (Pan)
PTEN Q171E Akt Inhibitor (Pan)
PTEN Y178del Akt Inhibitor (Pan)
PTEN M35V Akt Inhibitor (Pan)
PTEN F271S Akt Inhibitor (Pan)
PTEN Q171* Akt Inhibitor (Pan)
PTEN R15S Akt Inhibitor (Pan)
PTEN E7* Akt Inhibitor (Pan)
PTEN R130Q Akt Inhibitor (Pan)
PTEN V255A Akt Inhibitor (Pan)
PTEN H123D Akt Inhibitor (Pan)
PTEN D24H Akt Inhibitor (Pan)
PTEN I135K Akt Inhibitor (Pan)
PTEN D22E Akt Inhibitor (Pan)
PTEN P96Q Akt Inhibitor (Pan)
PTEN F347L Akt Inhibitor (Pan)
PTEN Y65* Akt Inhibitor (Pan)
PTEN D268Gfs*30 Akt Inhibitor (Pan)
PTEN V119fs Akt Inhibitor (Pan)
PTEN P95R Akt Inhibitor (Pan)
PTEN V275G Akt Inhibitor (Pan)
PTEN F56C Akt Inhibitor (Pan)
PTEN N48K Akt Inhibitor (Pan)
PTEN D107G Akt Inhibitor (Pan)
PTEN F341V Akt Inhibitor (Pan)
PTEN Y155N Akt Inhibitor (Pan)
PTEN C124G Akt Inhibitor (Pan)
PTEN H118fs Akt Inhibitor (Pan)
PTEN L247_P248del Akt Inhibitor (Pan)
PTEN C124R Akt Inhibitor (Pan)
PTEN G129R Akt Inhibitor (Pan)
PTEN A151P Akt Inhibitor (Pan)
PTEN E235* Akt Inhibitor (Pan)
PTEN T321* Akt Inhibitor (Pan)
PTEN K13E Akt Inhibitor (Pan)
PTEN V290* Akt Inhibitor (Pan)
PTEN E99* Akt Inhibitor (Pan)
PTEN V54del Akt Inhibitor (Pan)
PTEN R142W Akt Inhibitor (Pan)
PTEN A34D Akt Inhibitor (Pan)
PTEN D107Y Akt Inhibitor (Pan)
PTEN V275* Akt Inhibitor (Pan)
PTEN D24G Akt Inhibitor (Pan)
PTEN Q214* Akt Inhibitor (Pan)
PTEN D109* Akt Inhibitor (Pan)
PTEN R41* Akt Inhibitor (Pan)
PTEN F154L Akt Inhibitor (Pan)
PTEN P96R Akt Inhibitor (Pan)
PTEN D331fs Akt Inhibitor (Pan)
PTEN R173fs Akt Inhibitor (Pan)
PTEN W274* Akt Inhibitor (Pan)
PTEN Y76fs Akt Inhibitor (Pan)
PTEN K254Rfs*42 Akt Inhibitor (Pan)
PTEN Y155C Akt Inhibitor (Pan)
PTEN D326Y Akt Inhibitor (Pan)
PTEN S10I Akt Inhibitor (Pan)
PTEN K128E Akt Inhibitor (Pan)
PTEN C124L Akt Inhibitor (Pan)
PTEN D24Y Akt Inhibitor (Pan)
PTEN V290Sfs*8 Akt Inhibitor (Pan)
PTEN Y188del Akt Inhibitor (Pan)
PTEN L320S Akt Inhibitor (Pan)
PTEN P38L Akt Inhibitor (Pan)
PTEN Y174* Akt Inhibitor (Pan)
PTEN V45del Akt Inhibitor (Pan)
PTEN G132del Akt Inhibitor (Pan)
PTEN F145* Akt Inhibitor (Pan)
PTEN K6fs Akt Inhibitor (Pan)
PTEN E256* Akt Inhibitor (Pan)
PTEN Y174D Akt Inhibitor (Pan)
PTEN V290fs Akt Inhibitor (Pan)
PTEN R130fs Akt Inhibitor (Pan)
PTEN K197* Akt Inhibitor (Pan)
PTEN L112P Akt Inhibitor (Pan)
PTEN G143fs Akt Inhibitor (Pan)
PTEN Y27N Akt Inhibitor (Pan)
PTEN C124N Akt Inhibitor (Pan)
PTEN M264R Akt Inhibitor (Pan)
PTEN N323Kfs*2 Akt Inhibitor (Pan)
PTEN E288fs Akt Inhibitor (Pan)
PTEN T382S Akt Inhibitor (Pan)
PTEN K13* Akt Inhibitor (Pan)
PTEN L57fs Akt Inhibitor (Pan)
PTEN T277N Akt Inhibitor (Pan)
PTEN C136Y Akt Inhibitor (Pan)
PTEN I33S Akt Inhibitor (Pan)
PTEN V54fs Akt Inhibitor (Pan)
PTEN K260* Akt Inhibitor (Pan)
PTEN R335L Akt Inhibitor (Pan)
PTEN K6del Akt Inhibitor (Pan)
PTEN E291Gfs*7 Akt Inhibitor (Pan)
PTEN N329fs Akt Inhibitor (Pan)
PTEN E284* Akt Inhibitor (Pan)
PTEN E288* Akt Inhibitor (Pan)
PTEN V166G Akt Inhibitor (Pan)
PTEN K6I Akt Inhibitor (Pan)
PTEN L23S Akt Inhibitor (Pan)
PTEN T167N Akt Inhibitor (Pan)
PTEN A72fs Akt Inhibitor (Pan)
PTEN K237fs Akt Inhibitor (Pan)
PTEN E157G Akt Inhibitor (Pan)
PTEN C124S Akt Inhibitor (Pan)
PTEN L325F Akt Inhibitor (Pan)
PTEN N276A Akt Inhibitor (Pan)
PTEN M35K Akt Inhibitor (Pan)
PTEN G251V Akt Inhibitor (Pan)
PTEN K289Nfs*8 Akt Inhibitor (Pan)
PTEN Y16fs Akt Inhibitor (Pan)
PTEN R14fs Akt Inhibitor (Pan)
PTEN H93P Akt Inhibitor (Pan)
PTEN L345Q Akt Inhibitor (Pan)
PTEN I122fs Akt Inhibitor (Pan)
PTEN M134L Akt Inhibitor (Pan)
PTEN V166Sfs*14 Akt Inhibitor (Pan)
PTEN W111G Akt Inhibitor (Pan)
PTEN M199del Akt Inhibitor (Pan)
PTEN K183Ifs*15 Akt Inhibitor (Pan)
PTEN L23F Akt Inhibitor (Pan)
PTEN Y225* Akt Inhibitor (Pan)
PTEN K102fs Akt Inhibitor (Pan)
PTEN D92Y Akt Inhibitor (Pan)
PTEN C105F Akt Inhibitor (Pan)
PTEN loss Akt Inhibitor (Pan)
PTEN Y240* Akt Inhibitor (Pan)
PTEN V119G Akt Inhibitor (Pan)
PTEN L57W Akt Inhibitor (Pan)
PTEN I101T Akt Inhibitor (Pan)
PTEN T131A Akt Inhibitor (Pan)
PTEN A39P Akt Inhibitor (Pan)
PTEN D326H Akt Inhibitor (Pan)
PTEN Q149* Akt Inhibitor (Pan)
PTEN Y336* Akt Inhibitor (Pan)
PTEN R130L Akt Inhibitor (Pan)
PTEN C71Y Akt Inhibitor (Pan)
PTEN Y178* Akt Inhibitor (Pan)
PTEN K163* Akt Inhibitor (Pan)
PTEN D92V Akt Inhibitor (Pan)
PTEN F21A Akt Inhibitor (Pan)
PTEN R130G Akt Inhibitor (Pan)
PTEN V343E Akt Inhibitor (Pan)
PTEN R161G Akt Inhibitor (Pan)
PTEN H123Y Akt Inhibitor (Pan)
PTEN E284fs Akt Inhibitor (Pan)
PTEN G132D Akt Inhibitor (Pan)
PTEN A126D Akt Inhibitor (Pan)
PTEN Q245* Akt Inhibitor (Pan)
PTEN L139* Akt Inhibitor (Pan)
PTEN L247* Akt Inhibitor (Pan)
PTEN D24V Akt Inhibitor (Pan)
PTEN D92H Akt Inhibitor (Pan)
PTEN N184Efs*16 Akt Inhibitor (Pan)
PTEN R173H Akt Inhibitor (Pan)
PTEN N48S Akt Inhibitor (Pan)
PTEN Y315* Akt Inhibitor (Pan)
PTEN D331Tfs*13 Akt Inhibitor (Pan)
PTEN L108H Akt Inhibitor (Pan)
PTEN A126fs Akt Inhibitor (Pan)
PTEN R159F Akt Inhibitor (Pan)
PTEN H61L Akt Inhibitor (Pan)
PTEN H61P Akt Inhibitor (Pan)
PTEN E157* Akt Inhibitor (Pan)
PTEN I101S Akt Inhibitor (Pan)
PTEN L193fs Akt Inhibitor (Pan)
PTEN G293fs Akt Inhibitor (Pan)
PTEN M134I Akt Inhibitor (Pan)
PTEN K13Q Akt Inhibitor (Pan)
PTEN W111* Akt Inhibitor (Pan)
PTEN A126V Akt Inhibitor (Pan)
PTEN D107V Akt Inhibitor (Pan)
PTEN Y46H Akt Inhibitor (Pan)
PTEN R142P Akt Inhibitor (Pan)
PTEN L57* Akt Inhibitor (Pan)
PTEN Y68N Akt Inhibitor (Pan)
PTEN Y188* Akt Inhibitor (Pan)
PTEN W111R Akt Inhibitor (Pan)
PTEN Q17* Akt Inhibitor (Pan)
PTEN G127* Akt Inhibitor (Pan)
PTEN S385* Akt Inhibitor (Pan)
PTEN Y155fs Akt Inhibitor (Pan)
PTEN S10del Akt Inhibitor (Pan)
PTEN M205I Akt Inhibitor (Pan)
PTEN N276K Akt Inhibitor (Pan)
PTEN H61R Akt Inhibitor (Pan)
PTEN V217G Akt Inhibitor (Pan)
PTEN H118P Akt Inhibitor (Pan)
PTEN Y138L Akt Inhibitor (Pan)
PTEN V133I Akt Inhibitor (Pan)
PTEN R234* Akt Inhibitor (Pan)
PTEN R15K Akt Inhibitor (Pan)
PTEN H123R Akt Inhibitor (Pan)
PTEN Y16D Akt Inhibitor (Pan)
PTEN R335* Akt Inhibitor (Pan)
PTEN A126P Akt Inhibitor (Pan)
PTEN D92G Akt Inhibitor (Pan)
PTEN K147* Akt Inhibitor (Pan)
PTEN I253N Akt Inhibitor (Pan)
PTEN C211* Akt Inhibitor (Pan)
PTEN S170I Akt Inhibitor (Pan)
PTEN Q171P Akt Inhibitor (Pan)
PTEN N117S Akt Inhibitor (Pan)
PTEN N323fs Akt Inhibitor (Pan)
PTEN T131L Akt Inhibitor (Pan)
PTEN R173C Akt Inhibitor (Pan)
PTEN H93D Akt Inhibitor (Pan)
PTEN S294fs Akt Inhibitor (Pan)
PTEN R130P Akt Inhibitor (Pan)
PTEN G36* Akt Inhibitor (Pan)
PTEN Y177C Akt Inhibitor (Pan)
PTEN T319* Akt Inhibitor (Pan)
PTEN V175E Akt Inhibitor (Pan)
PTEN H272P Akt Inhibitor (Pan)
PTEN Y65D Akt Inhibitor (Pan)
PTEN L152R Akt Inhibitor (Pan)
PTEN H123L Akt Inhibitor (Pan)
PTEN P38T Akt Inhibitor (Pan)
PTEN Y65C Akt Inhibitor (Pan)
PTEN E91* Akt Inhibitor (Pan)
PTEN E307* Akt Inhibitor (Pan)
PTEN Y46* Akt Inhibitor (Pan)
PTEN Y68D Akt Inhibitor (Pan)
PTEN Y27D Akt Inhibitor (Pan)
PTEN G156V Akt Inhibitor (Pan)
PTEN T277del Akt Inhibitor (Pan)
PTEN G165R Akt Inhibitor (Pan)
PTEN D252Y Akt Inhibitor (Pan)
PTEN S287* Akt Inhibitor (Pan)
PTEN K125L Akt Inhibitor (Pan)
PTEN L146* Akt Inhibitor (Pan)
PTEN R159S Akt Inhibitor (Pan)
PTEN A34P Akt Inhibitor (Pan)
PTEN K254fs Akt Inhibitor (Pan)
PTEN I101F Akt Inhibitor (Pan)
PTEN K6* Akt Inhibitor (Pan)
PTEN L265fs Akt Inhibitor (Pan)
PTEN negative Akt Inhibitor (Pan)
PTEN V217D Akt Inhibitor (Pan)
PTEN Y27fs Akt Inhibitor (Pan)
PTEN M134R Akt Inhibitor (Pan)
PTEN H141P Akt Inhibitor (Pan)
PTEN T321fs Akt Inhibitor (Pan)
PTEN D77* Akt Inhibitor (Pan)
PTEN R173P Akt Inhibitor (Pan)
PTEN M35R Akt Inhibitor (Pan)
PTEN G165* Akt Inhibitor (Pan)
PTEN K269* Akt Inhibitor (Pan)
PTEN Q298fs Akt Inhibitor (Pan)
PTEN K254* Akt Inhibitor (Pan)
PTEN Y27C Akt Inhibitor (Pan)
PTEN C124fs Akt Inhibitor (Pan)
PTEN I253* Akt Inhibitor (Pan)
PTEN Q261* Akt Inhibitor (Pan)
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
HRAS E162K missense unknown HRAS E162K does not lie within any known functional domains of the Hras protein (UniProt.org). E162K has been identified in the scientific literature (PMID: 22932669), but has not been biochemically characterized and therefore, its effect on Hras protein function is unknown (PubMed, Jul 2022).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA act mut breast cancer sensitive MK2206 Preclinical Actionable In a preclinical study, breast cancer cell lines harboring activating mutations in PIK3CA had increased sensitivity to MK2206 in cell culture (PMID: 22932669). 22932669