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Authors | G Garcia-Manero, H Yang, Z Fang, HM Kantarjian, CD DiNardo, EJ Jabbour, N Pemmaraju, N Daver, R Delumpa, C Loiselle, S Rivera, K Anderson, B Yearby, S Denton, W Smith, K Tiefenwerth, H Iwamura, T Gipson, M Rosner, TJ Myers, LJ Paradiso | ||||||||||||
Title | Phase 1 Results of FF-10501-01, a Novel Inosine 5'-Monophosphate Dehydrogenase Inhibitor, in Advanced Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS), Including Hypomethylating Agent (HMA) Failures | ||||||||||||
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URL | http://www.bloodjournal.org/content/128/22/1640?sso-checked=true | ||||||||||||
Abstract Text | Blood 2016 128:1640 |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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FF-10501-01 | FF-10501-01 | 0 | 1 |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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FF-10501-01 | FF-10501 | FF-10501-01 is a competitive inhibitor of inosine 5'- monophosphate dehydrogenase (IMPDH) which controls guanine nucleotide synthesis, therefore results in apoptosis of tumor cells (Blood 2016 128:1640, PMID: 28599189, PMID: 32264726). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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