Therapy Detail

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Therapy Name FF-10501-01
Synonyms
Therapy Description

FF-10501-01 is a competitive inhibitor of inosine 5'- monophosphate dehydrogenase (IMPDH) which controls guanine nucleotide synthesis, therefore results in apoptosis of tumor cells (Blood 2016 128:1640).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
FF-10501-01 FF-10501-01 is a competitive inhibitor of inosine 5'- monophosphate dehydrogenase (IMPDH) which controls guanine nucleotide synthesis, therefore results in apoptosis of tumor cells (Blood 2016 128:1640).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown acute myeloid leukemia not applicable FF-10501-01 Phase I Actionable In a Phase I trial, FF-10501-01 demonstrated safety and preliminary efficacy, resulted in stable disease control with no disease progression over 3-24 cycles of treatment in 34.8% (8/23) of acute myeloid leukemia patients, including 2 patients achieved partial response (Blood 128 (22):1640). detail...
Unknown unknown myelodysplastic syndrome not applicable FF-10501-01 Phase I Actionable In a Phase I trial, FF-10501-01 demonstrated safety and preliminary efficacy, resulted in stable disease control with no disease progression over 3-14 cycles of treatment in 50% (3/6) of myelodysplastic syndrome patients, including 1 patient achieved complete marrow response (Blood 128 (22):1640). detail...

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status
NCT02193958 Phase Ib/II FF-10501-01 Study of FF-10501-01 in Patients With Relapsed or Refractory Hematological Malignancies Completed


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