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Ref Type
Authors Toan Pham, Shienny Sampurno, Lloyd Pereira, Sara Roth, Vignesh Narasimhan, Sandra Carpinteri, Alexander Heriot, Jayesh Desai, Robert G.Ramsay
Title Cancer Vaccine Targeting MYB in Colorectal Cancer: From Pre-Clinical Model to Clinical Trial
Abstract Text Gastroenterology Volume 154, Issue 6, Supplement 1, May 2018, Pages S-1269


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
TetMYB TetMYB 1 0
Drug Name Trade Name Synonyms Drug Classes Drug Description
TetMYB MYB vaccine TetMYB is a DNA vaccine comprised of a modified full-length MYB coding region linked to tetanus peptides, which results in enhanced immune response to MYB expressing tumor cells (Gastroenterology, Volume 154, Issue 6, Supplement 1, May 2018, Pages S-1269, PMID: 25671128, PMID: 31650066).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
APC mutant colon adenoma predicted - sensitive TetMYB Preclinical Actionable In a preclinical study, TetMYB treatment resulted in improved median survival compared to control (356 vs 183 days) in APC-driven mouse models of colon adenoma (Gastroenterology, Volume 154, Issue 6, Supplement 1, May 2018, Pages S-1269). detail...