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Authors | Justin Cidado, Theresa Proia, Scott Boiko, Maryann San Martin, Steven Criscione, Douglas Ferguson, Wenlin Shao and Lisa Drew | ||||||||||||
Title | AZD4573, a novel CDK9 inhibitor, rapidly induces cell death in hematological tumor models through depletion of Mcl1 | ||||||||||||
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URL | http://cancerres.aacrjournals.org/content/78/13_Supplement/310.short | ||||||||||||
Abstract Text | Cancer Res 2018;78(13 Suppl):Abstract nr 310 |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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AZD4573 | AZD-4573|AZD 4573 | CDK9 Inhibitor 21 | AZD4573 is a selective inhibitor of Cdk9 that suppresses Mcl1 expression thus leads to apoptosis in tumor cells (Cancer Res 2018;78(13 Suppl):Abstract nr 310, PMID: 32175313, PMID: 31699827). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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