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Ref Type
Authors N Brooks, R DeWalt, S Boulet, ZH Lu, L Kays, R cavitt, S Gomez, J Strelow, P Milligan, K Roth, R Bauer, S Antonysamy, P Hahn, Z Rankovic, D McCann, G Mo, R Tiu, T Burkholder, S Geeganage, R Gilmour
Title Identification and characterization of LY3410738, a novel covalent inhibitor of cancer-associated mutant Isocitrate Dehydrogenase 1 (IDH1)
Abstract Text AACR Annual Meeting 2019, Abstract LB-274


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
IDH1 mutant acute myeloid leukemia predicted - sensitive LY3410738 Preclinical - Pdx & cell culture Actionable In a preclinical study, LY3410738 reversed mutant IDH1-induced differentiation block in patient-derived acute myeloid leukemia (AML) cells, inhibited 2-HG production, induced differentiation, and eliminated AML cells in patient-derived orthotopic animal models of IDH1-mutant AML (AACR 2019 Annual Meeting, Abstract LB-274). detail...