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Ref Type
PMID
Authors A Drilon, F Barlesi, F D Braud, B C Cho, M-J Ahn, S Siena, MG. Krebs, C-C Lin, T John, DSW Tan, T Seto, R Dziadziuszko, H-T Arkenau, C Rolfo, J Wolf, C Ye, T Riehl, S Eng and RC. Doebele
Title Entrectinib in locally advanced or metastatic ROS1 fusion-positive non-small cell lung cancer (NSCLC): Integrated analysis of ALKA-372-001, STARTRK-1 and STARTRK-2
Journal Vol Issue Date Pages Journal Short Title
Cancer Res
URL https://cancerres.aacrjournals.org/content/79/13_Supplement/CT192
Abstract Text Cancer Res 2019;79(13 Suppl):Abstract nr CT192.

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ROS1 positive lung non-small cell carcinoma sensitive Entrectinib FDA approved Actionable In a combined analysis of 3 clinical trials (ALKA-372-001, STARTRK-1, STARTRK-2) that supported FDA approval, Rozlytrek (entrectinib) treatment resulted in an objective response rate of 77% (41/53), a median duration of response of 25 months in patients with ROS1 fusion positive non-small cell lung cancer, with median progression-free survival of 26 and 14 months for patients without (n=30) and with (n=23) CNS disease, respectively (Cancer Res 2019;79(13 Suppl):Abstract nr CT192; NCT02097810; NCT02568267). detail... detail...