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PMID
Authors Dejan Juric, Jean-Charles Soria, Sunil Sharma, Udai Banerji, Analia Azaro, Jayesh Desai, Francois Philippe Ringeisen, Audrey Kaag, Rajkumar Radhakrishnan, Florence Hourcade-Potelleret, Heiko Maacke, Jordi Rodon Ahnert
Title A phase 1b dose-escalation study of BYL719 plus binimetinib (MEK162) in patients with selected advanced solid tumors.
Journal J Clin Oncol
Vol 32
Issue 5s
Date
URL http://meetinglibrary.asco.org/content/129278-144
Abstract Text J Clin Oncol 32:5s, 2014 (suppl; abstr 9051)

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
HRAS mutant ovarian cancer predicted - sensitive Alpelisib + Binimetinib Phase Ib/II Actionable In a Phase Ib study, Alpelisib (BYL719) in combination with Binimetinib (MEK162) demonstrated preliminary safety and efficacy in patients with RAS-mutant advanced solid tumors, including patients with ovarian cancer (J Clin Oncol 32:5s, 2014 (suppl; abstr 9051). detail...