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Ref Type Journal Article
PMID (16774045)
Authors Stoeckel J, Hay JG
Title Drug evaluation: Reolysin--wild-type reovirus as a cancer therapeutic.
Journal Current opinion in molecular therapeutics
Vol 8
Issue 3
Date 2006 Jun
URL
Abstract Text Oncolytics Biotech is developing an oncolytic reovirus therapy (Reolysin, Reosyn) for the potential treatment of a variety of Ras-mediated cancers, including glioma and medulloblastoma, pancreatic, prostate, breast, lung, colon, bladder, ovarian and hematological cancers, and melanoma and childhood sarcoma. Phase I/II clinical trials in recurrent malignant glioma began in 2002.

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Molecular Profile Treatment Approach
HRAS G13C RAS Inhibitor (Pan)
HRAS Q61T RAS Inhibitor (Pan)
HRAS A146T RAS Inhibitor (Pan)
HRAS G13D RAS Inhibitor (Pan)
NRAS G12C RAS Inhibitor (Pan)
NRAS G12S RAS Inhibitor (Pan)
HRAS Q61H RAS Inhibitor (Pan)
HRAS G13S RAS Inhibitor (Pan)
NRAS Q61K RAS Inhibitor (Pan)
HRAS K117N RAS Inhibitor (Pan)
NRAS G12D RAS Inhibitor (Pan)
HRAS G13I RAS Inhibitor (Pan)
NRAS A146T RAS Inhibitor (Pan)
HRAS G12E RAS Inhibitor (Pan)
NRAS G12X RAS Inhibitor (Pan)
NRAS T58I RAS Inhibitor (Pan)
HRAS Q61A RAS Inhibitor (Pan)
HRAS Q61X RAS Inhibitor (Pan)
HRAS Q61G RAS Inhibitor (Pan)
HRAS G13V RAS Inhibitor (Pan)
NRAS T50I RAS Inhibitor (Pan)
HRAS G12C RAS Inhibitor (Pan)
NRAS S65C RAS Inhibitor (Pan)
HRAS Q61Y RAS Inhibitor (Pan)
HRAS A146V RAS Inhibitor (Pan)
HRAS G12N RAS Inhibitor (Pan)
NRAS G13R RAS Inhibitor (Pan)
HRAS G12S RAS Inhibitor (Pan)
HRAS G13X RAS Inhibitor (Pan)
HRAS Q61P RAS Inhibitor (Pan)
HRAS Q61L RAS Inhibitor (Pan)
HRAS G12R RAS Inhibitor (Pan)
NRAS Q61H RAS Inhibitor (Pan)
NRAS G13C RAS Inhibitor (Pan)
HRAS G12K RAS Inhibitor (Pan)
HRAS G13R RAS Inhibitor (Pan)
NRAS G13X RAS Inhibitor (Pan)
HRAS G12T RAS Inhibitor (Pan)
HRAS G12I RAS Inhibitor (Pan)
NRAS G13S RAS Inhibitor (Pan)
HRAS Q61I RAS Inhibitor (Pan)
NRAS G13D RAS Inhibitor (Pan)
HRAS G12Q RAS Inhibitor (Pan)
HRAS G12X RAS Inhibitor (Pan)
HRAS G12Y RAS Inhibitor (Pan)
HRAS G12L RAS Inhibitor (Pan)
HRAS G12H RAS Inhibitor (Pan)
NRAS Q61X RAS Inhibitor (Pan)
HRAS G12D RAS Inhibitor (Pan)
NRAS Q61E RAS Inhibitor (Pan)
HRAS Q61F RAS Inhibitor (Pan)
NRAS G12A RAS Inhibitor (Pan)
NRAS G13V RAS Inhibitor (Pan)
NRAS E63K RAS Inhibitor (Pan)
HRAS G12V RAS Inhibitor (Pan)
HRAS Q61N RAS Inhibitor (Pan)
HRAS K117E RAS Inhibitor (Pan)
HRAS A59T RAS Inhibitor (Pan)
HRAS Q61V RAS Inhibitor (Pan)
HRAS K117R RAS Inhibitor (Pan)
HRAS Q61E RAS Inhibitor (Pan)
HRAS G13T RAS Inhibitor (Pan)
NRAS Q61L RAS Inhibitor (Pan)
HRAS Q61C RAS Inhibitor (Pan)
NRAS G12R RAS Inhibitor (Pan)
HRAS Q61R RAS Inhibitor (Pan)
HRAS T58I RAS Inhibitor (Pan)
HRAS G12F RAS Inhibitor (Pan)
NRAS Q61R RAS Inhibitor (Pan)
NRAS G13A RAS Inhibitor (Pan)
HRAS D33N RAS Inhibitor (Pan)
HRAS Q61K RAS Inhibitor (Pan)
HRAS inact mut RAS Inhibitor (Pan)
HRAS Q61W RAS Inhibitor (Pan)
NRAS G12V RAS Inhibitor (Pan)
HRAS G12M RAS Inhibitor (Pan)
HRAS G12W RAS Inhibitor (Pan)
NRAS G12N RAS Inhibitor (Pan)
NRAS G12Y RAS Inhibitor (Pan)
HRAS G12A RAS Inhibitor (Pan)
NRAS G60E RAS Inhibitor (Pan)
HRAS Q61M RAS Inhibitor (Pan)
NRAS Q61P RAS Inhibitor (Pan)
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References