Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
Ref Type | |
PMID | (32923889) |
Authors | Batalini F, Moulder SL, Winer EP, Rugo HS, Lin NU, Wulf GM |
Title | Response of Brain Metastases From PIK3CA-Mutant Breast Cancer to Alpelisib. |
Journal | JCO precision oncology |
Vol | 4 |
Issue | |
Date | 2020 |
URL | |
Abstract Text |
Molecular Profile | Treatment Approach |
---|
Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
---|
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
---|---|---|---|---|---|
PIK3CA | E563K | missense | unknown | PIK3CA E563K lies within the PIK helical domain of the Pik3ca protein (UniProt.org). E563K has been identified in the scientific literature (PMID: 32923889), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Feb 2021). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|