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Ref Type
PMID (32923889)
Authors Batalini F, Moulder SL, Winer EP, Rugo HS, Lin NU, Wulf GM
Title Response of Brain Metastases From PIK3CA-Mutant Breast Cancer to Alpelisib.
Journal JCO precision oncology
Vol 4
Issue
Date 2020
URL
Abstract Text

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
PIK3CA E563K missense unknown PIK3CA E563K lies within the PIK helical domain of the Pik3ca protein (UniProt.org). E563K has been identified in the scientific literature (PMID: 32923889), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Feb 2021).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References