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PMID | (32923889) | ||||||||||||
Authors | Batalini F, Moulder SL, Winer EP, Rugo HS, Lin NU, Wulf GM | ||||||||||||
Title | Response of Brain Metastases From PIK3CA-Mutant Breast Cancer to Alpelisib. | ||||||||||||
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Abstract Text |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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PIK3CA | E563K | missense | unknown | PIK3CA E563K lies within the PIK helical domain of the Pik3ca protein (UniProt.org). E563K has been identified in the scientific literature (PMID: 32923889), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Mar 2024). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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