Reference Detail

Ref Type

Journal Article

PMID

(32185139)

Authors

Wu S, Zhou J, Zhang K, Chen H, Luo M, Lu Y, Sun Y, Chen Y

Title

Molecular Mechanisms of PALB2 Function and Its Role in Breast Cancer Management.

Journal	Vol	Issue	Date	Pages	Journal Short Title
Frontiers in oncology	10		2020	301	Front Oncol

URL

Abstract Text

Partner and localizer of BRCA2 (PALB2) is vital for homologous recombination (HR) repair in response to DNA double-strand breaks (DSBs). PALB2 functions as a tumor suppressor and participates in the maintenance of genome integrity. In this review, we summarize the current knowledge of the biological roles of the multifaceted PALB2 protein and of its regulation. Moreover, we describe the link between PALB2 pathogenic variants (PVs) and breast cancer predisposition, aggressive clinicopathological features, and adverse clinical prognosis. We also refer to both the opportunities and challenges that the identification of PALB2 PVs provides in breast cancer genetic counseling and precision medicine.

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Molecular Profile	Treatment Approach
PALB2 K1098*	PARP Inhibitor (Pan)
PALB2 S979Vfs*11	PARP Inhibitor (Pan)
PALB2 N821Tfs*25	PARP Inhibitor (Pan)
PALB2 L35F	PARP Inhibitor (Pan)
PALB2 Q1056*	PARP Inhibitor (Pan)
PALB2 S254Ifs*3	PARP Inhibitor (Pan)
PALB2 K862Rfs*9	PARP Inhibitor (Pan)
PALB2 R414*	PARP Inhibitor (Pan)
PALB2 T494Lfs*67	PARP Inhibitor (Pan)
PALB2 L947F	PARP Inhibitor (Pan)
PALB2 Q790*	PARP Inhibitor (Pan)
PALB2 K346Tfs*13	PARP Inhibitor (Pan)
PALB2 inact mut	PARP Inhibitor (Pan)
PALB2 L24F	PARP Inhibitor (Pan)
PALB2 K908fs	PARP Inhibitor (Pan)
PALB2 W898*	PARP Inhibitor (Pan)
PALB2 G808*	PARP Inhibitor (Pan)
PALB2 del	PARP Inhibitor (Pan)
PALB2 R1086Efs*9	PARP Inhibitor (Pan)
PALB2 H46Y	PARP Inhibitor (Pan)
PALB2 E1010*	PARP Inhibitor (Pan)
PALB2 loss	PARP Inhibitor (Pan)
PALB2 Q1023*	PARP Inhibitor (Pan)
PALB2 N344Tfs*2	PARP Inhibitor (Pan)

Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role

Therapy Name	Drugs	Efficacy Evidence	Clinical Trials

Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description

Gene	Variant	Impact	Protein Effect	Variant Description	Associated with drug Resistance

Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References