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Ref Type Journal Article
PMID (19629070)
Authors Engelman JA
Title Targeting PI3K signalling in cancer: opportunities, challenges and limitations.
Journal Nature reviews. Cancer
Vol 9
Issue 8
Date 2009 Aug
URL
Abstract Text There are ample genetic and laboratory studies that suggest the PI3K-Akt pathway is vital to the growth and survival of cancer cells. Inhibitors targeting this pathway are entering the clinic at a rapid pace. In this Review, the therapeutic potential of drugs targeting PI3K-Akt signalling for the treatment of cancer is discussed. I focus on the advantages and drawbacks of different treatment strategies for targeting this pathway, the cancers that might respond best to these therapies and the challenges and limitations that confront their clinical development.

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Molecular Profile Treatment Approach
NRAS G13S PI3K Inhibitor (Pan)
NRAS Q61L PIK3CA inhibitor
NRAS T50I PIK3CA inhibitor
NRAS G13X PI3K Inhibitor (Pan)
NRAS A146T PI3K Inhibitor (Pan)
NRAS T50I PI3K Inhibitor (Pan)
NRAS Q61L PI3K Inhibitor (Pan)
NRAS G12R PI3K Inhibitor (Pan)
NRAS Q61K PIK3CA inhibitor
NRAS G12S PI3K Inhibitor (Pan)
NRAS G13C PI3K Inhibitor (Pan)
NRAS G60E PI3K Inhibitor (Pan)
NRAS I24N PI3K Inhibitor (Pan)
NRAS G12R PIK3CA inhibitor
NRAS G12C PI3K Inhibitor (Pan)
NRAS G13A PIK3CA inhibitor
NRAS Q61K PI3K Inhibitor (Pan)
NRAS S65C PIK3CA inhibitor
NRAS G12Y PIK3CA inhibitor
NRAS G12C PIK3CA inhibitor
NRAS G13V PI3K Inhibitor (Pan)
NRAS E63K PI3K Inhibitor (Pan)
NRAS G13R PIK3CA inhibitor
NRAS Q61H PI3K Inhibitor (Pan)
NRAS G12N PIK3CA inhibitor
NRAS G12A PI3K Inhibitor (Pan)
NRAS G12X PIK3CA inhibitor
NRAS G13S PIK3CA inhibitor
NRAS Q61P PIK3CA inhibitor
NRAS G12D PI3K Inhibitor (Pan)
NRAS Q61R PIK3CA inhibitor
NRAS G13X PIK3CA inhibitor
NRAS G13A PI3K Inhibitor (Pan)
NRAS E63K PIK3CA inhibitor
NRAS Q61H PIK3CA inhibitor
NRAS G12V PIK3CA inhibitor
NRAS G60E PIK3CA inhibitor
NRAS T58I PIK3CA inhibitor
NRAS Q61E PIK3CA inhibitor
NRAS G12V PI3K Inhibitor (Pan)
NRAS Q61X PIK3CA inhibitor
NRAS T58I PI3K Inhibitor (Pan)
NRAS G12Y PI3K Inhibitor (Pan)
NRAS G12D PIK3CA inhibitor
NRAS A146T PIK3CA inhibitor
NRAS G12A PIK3CA inhibitor
NRAS Q61R PI3K Inhibitor (Pan)
NRAS G13D PI3K Inhibitor (Pan)
NRAS I24N PIK3CA inhibitor
NRAS S65C PI3K Inhibitor (Pan)
NRAS G12X PI3K Inhibitor (Pan)
NRAS G12N PI3K Inhibitor (Pan)
NRAS G13R PI3K Inhibitor (Pan)
NRAS Q61P PI3K Inhibitor (Pan)
NRAS Q61X PI3K Inhibitor (Pan)
NRAS G13V PIK3CA inhibitor
NRAS G12S PIK3CA inhibitor
NRAS G13D PIK3CA inhibitor
NRAS G13C PIK3CA inhibitor
NRAS Q61E PI3K Inhibitor (Pan)
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References