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Ref Type Journal Article
PMID (34895532)
Authors Andrews JP, Coleman C, Hastings C, Sun PP
Title Oncogenic NTRK fusion in congenital spinal cord glioblastoma: sequencing directs treatment.
URL
Abstract Text

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NTRK1 fusion glioblastoma predicted - sensitive Carboplatin + Etoposide + Larotrectinib Case Reports/Case Series Actionable In a clinical case study, Vitrakvi (larotrectinib), Paraplatin (carboplatin), and Vepesid (etoposide) combination treatment resulted in complete tumor regression after 8 weeks in a pediatric patient with congenital spinal cord glioblastoma harboring an NTRK1 fusion, who remained tumor-free at 17 months (PMID: 34895532). 34895532