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Ref Type
Authors Michael Y. Choi, Jessie-Farah Fecteau, Jeff Brown, Alan Lau, and Thomas J. Kipps
Title Abstract 5485: Induction of proliferation sensitizes chronic lymphocytic leukemia cells to apoptosis mediated by the ATR inhibitor AZD6738
Abstract Text Cancer Res October 1, 2014 74; 5485


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATR over exp chronic lymphocytic leukemia predicted - sensitive Ceralasertib Preclinical Actionable In a preclinical study, chronic lymphocytic leukemia cells expressing ATR were sensitive to AZD6738 (Cancer Res October 1, 2014 74; 5485). detail...