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Ref Type
Authors Cortes, Jorge E., Faderl, Stefan, Pagel, John, Jung, Chul Won, Yoon, Sung-Soo, Koh, Youngil, Pardanani, Animesh Dev, Hauptschein, Robert S, Lee, Kyoung-June, Lee, Je-Hwan
Title Phase 1 study of CWP232291 in relapsed/refractory acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).
Abstract Text


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CTNNB1 amp acute myeloid leukemia predicted - sensitive CWP232291 Phase I Actionable In a Phase I trial, CWP232291 reduced beta-catenin expression and demonstrated safety and preliminary efficacy in acute myeloid leukemia (J Clin Oncol (Meeting Abstracts) 2015 33: 7044)). detail...