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Ref Type
PMID
Authors Joaquin Mateo, S. Sandhu, S. Miranda, S. Carreira, S. Jain, C. Ralph, A. Protheroe, S. Hussain, R. Jones, T. Elliot, U. McGovern, A. Gillman, C. Paulding, H. Mossop, N.Porta, D. Bianchini, Z. Zafeiriou, G.Boysen, D. N. Rodrigues, et. al.
Title DNA repair defects and antitumor activity with PARP inhibition: TOPARP, a phase II trial of olaparib in metastatic castration resistant prostate cancer
Journal Cancer Res August 1, 2015 75:CT322
Vol
Issue
Date August 1, 2015
URL http://cancerres.aacrjournals.org/content/75/15_Supplement/CT322.short
Abstract Text doi: 10.1158/1538-7445.AM2015-CT32 Cancer Res August 1, 2015 75; CT322

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown prostate cancer not applicable Olaparib Phase II Actionable In a Phase II clinical trial, 86.7% (13/15) of metastatic castration-resistant prostate cancer patients with mutations in DNA repair genes demonstrated response to Lynparza (olaparib) treatment (Cancer Res August 1, 2015 75:CT322). detail...
ATM mutant prostate cancer sensitive Olaparib Phase II Actionable In a Phase II clinical trial, 80% (4/5) of metastatic castration-resistant prostate cancer patients with ATM truncation mutations demonstrated response to Lynparza (olaparib) treatment (Cancer Res August 1, 2015 75:CT322). detail...