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Ref Type
PMID
Authors Adi Diab, Alison Martin, Lauren Simpson, Alain Patrick Algazi, Purvi Chawla, Dae Won Kim, Sourav Santra, Vruti Patel, Nitin Jadhav, Dhiraj Abhyankar, Michael A. Davies, Shama C. Buch, Kevin Kim, Adil Daud
Title Phase I trial of the CDK 4/6 inhibitor, P1446A-05 (voruciclib) in combination with the BRAF inhibitor (BRAFi), vemurafenib in advanced, BRAF-mutant melanoma.
Journal Vol Issue Date Pages Journal Short Title
J Clin Oncol
URL http://meetinglibrary.asco.org/content/153239-156
Abstract Text J Clin Oncol 33, 2015 (suppl; abstr 9076)

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Voruciclib Voruciclib 0 1
Drug Name Trade Name Synonyms Drug Classes Drug Description
Voruciclib P1446A-05 CDK4/6 Inhibitor 13 Voruciclib (P1446A-05) is a selective CDK4/6 inhibitor that results in cell cycle arrest and apoptosis in cancer cells (J Clin Oncol 33, 2015 (suppl; abstr 9076), PMID: 32296028).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF mutant melanoma sensitive Vemurafenib + Voruciclib Phase I Actionable In a Phase I trial, Voruciclib (P1446A-05) and Zelboraf (vemurafenib) combination therapy demonstrated safety and preliminary efficacy, resulted in complete response in 33% (1/3) and partial response in 67% (2/3) of BRAFi-naïve melanoma patients harboring BRAF mutations (J Clin Oncol 33, 2015 (suppl; abstr 9076)). detail...