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Ref Type
Authors H.Nokihara, T. Hida, M. Kondo, Y. Hak Kim, K. Azuma, T. Seto, Y.Takiguchi, M. Nishio, H. Yoshioka, F. Imamura, K.Hotta, S. Watanabe, K. Goto, K. Nakagawa, T. Mitsudomi, N.Yamamoto, H. Kuriki, R. Asabe, T. Tanaka, T. Tamura
Title Alectinib (ALC) versus crizotinib (CRZ) in ALK-inhibitor naive ALK-positive non-small cell lung cancer (ALK+ NSCLC): Primary results from the J-ALEX study.
Abstract Text J Clin Oncol 34, 2016 (suppl; abstr 9008)


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK fusion lung non-small cell carcinoma sensitive Alectinib Phase III Actionable In a Phase III trial, treatment with Alecensa (alectinib) resulted in improved progression-free survival compared to treatment with Xalkori (crizotinib) (HR=0.34) in ALK-positive non-small cell lung cancer patients (J Clin Oncol 34, 2016 (suppl; abstr 9008)). detail...