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Ref Type
Authors Courtney D DiNardo, Aaron D. Schimmer, Karen W.L. Yee, Andreas Hochhaus, Alwin Kraemer, Richard D. Carvajal, Filip Janku, Philippe Bedard, Cecilia Carpio, Antje Wick, Gary K. Schwartz, Patrick Schöffski, Patrick Wen, Martin J. van den Bent et. al.
Title A Phase I Study of IDH305 in Patients with Advanced Malignancies Including Relapsed/Refractory AML and MDS That Harbor IDH1R132 Mutations
Abstract Text Blood 2016 128 (22):1073


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
IDH1 R132X acute myeloid leukemia sensitive IDH305 Phase I Actionable In a Phase I trial, IDH305 treatment resulted in objective response in 33% (7/21) of acute myeloid leukemia patients harboring IDH1 R132 mutations, including complete remission in 3 (14%) and partial remission in 4 (19%) patients (Blood 2016 128 (22):1073). detail...