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Ref Type
PMID
Authors
Title Use of combination treatment with the investigational RAF kinase inhibitor MLN2480 and the investigational MEK kinase inhibitor TAK-733 on the growth of BRAF-mutant and RAS-mutant preclinical models of melanoma and CRC.
Journal Vol Issue Date Pages Journal Short Title
J Clin Oncol 31, 2013 (suppl; abstr e13529)
URL http://meetinglibrary.asco.org/content/114757-132
Abstract Text

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF mutant melanoma sensitive Tovorafenib Preclinical - Cell line xenograft Actionable In a preclinical study, Tovorafenib (MLN2480) demonstrated efficacy in BRAF mutant xenograft models of melanoma and colorectal cancer (J Clin Oncol 31, 2013 (suppl; abstr e13529)). detail...
BRAF mutant colorectal cancer sensitive Tovorafenib Preclinical - Cell line xenograft Actionable In a preclinical study, Tovorafenib (MLN2480) demonstrated efficacy in BRAF mutant xenograft models of melanoma and colorectal cancer (J Clin Oncol 31, 2013 (suppl; abstr e13529)). detail...