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Ref Type
Authors Drew W. Rasco, Ryan J. Sullivan, Nehal J. Lakhani, Sanjeeva Reddy, Niranjan Sathyanarayana Rao, Louis J. Denis, Anthony W. Tolcher, Keith Flaherty
Title ASN003, a highly selective BRAF and PI3K inhibitor: Preclinical and phase 1 clinical data in patients with advanced solid tumors
Abstract Text J Clin Oncol 35, 2017 (suppl; abstr e14102)


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
ASN003 ASN003 4 1
Drug Name Trade Name Synonyms Drug Classes Drug Description
ASN003 ASN-003|ASN 003 BRAF Inhibitor 25 PIK3CA inhibitor 23 PIK3CG inhibitor 10 ASN003 is a small molecule inhibitor of BRAF, PIK3CA, and PIK3CG, which may result in inhibition of cell proliferation and antitumor activity (J Clin Oncol 35, 2017 (suppl; abstr e14102)).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600X melanoma sensitive ASN003 Preclinical - Pdx Actionable In a preclinical study, melanoma patient derived xenograft (PDX) model harboring a BRAF V600 mutation demonstrated antitumor activity when treated with ASN003 (J Clin Oncol 35, 2017 (suppl; abstr e14102)). detail...