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Ref Type
Authors Naoise C Synnott, Matthias R Bauer, Stephen F. Madden, Alyson M. Murray, Rut Klinger, Norma O'Donovan, Darran O'Connor, William M. Gallagher, John Crown, Alan R Fersht, Michael J. Duffy
Title Targeting mutant p53 with PK11007: A new approach for the treatment of patients with triple-negative breast cancer?
Abstract Text J Clin Oncol 35, 2017 (suppl; abstr e14099)


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 mutant breast cancer sensitive PK11007 Preclinical - Cell culture Actionable In a preclinical study, TP53-mutated breast cancer cell lines demonstrated increased sensitivity to PK11007 compared to TP53-wild type cells in culture, regardless of Esr1 and Erbb2 (Her2) status (J Clin Oncol 35, 2017 (suppl; abstr e14099)). detail...