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Therapy Name BAY2666605
Synonyms
Therapy Description

BAY2666605 induces formation of the SLFN12-PDE3A complex, leading to stimulation of SLFN12 activity and decreased inhibition of PDE3A enzymatic activity, potentially reducing cancer cell viability and inhibiting tumor growth (Cancer Res 2022;82(12_Suppl):Abstract nr 2663).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
BAY2666605 BAY 2666605|BAY-2666605|Doxorubicin-loaded EGFR-targeting Nanocells BAY2666605 induces formation of the SLFN12-PDE3A complex, leading to stimulation of SLFN12 activity and decreased inhibition of PDE3A enzymatic activity, potentially reducing cancer cell viability and inhibiting tumor growth (Cancer Res 2022;82(12_Suppl):Abstract nr 2663).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04809805 Phase I BAY2666605 A Study to Learn How Safe BAY2666605 is, How it Affects the Body, How it Moves Into, Through and Out of the Body, the Maximum Amount That Can be Given and Its Action Against Tumors in Adult Participants With Skin Cancer That Has Spread to Other Parts of the Body and Other Types of Advanced Cancer Terminated USA 0


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