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Therapy Name ORIC-114
Synonyms
Therapy Description

ORIC-114 is an inhibitor of EGFR and ERBB2 (HER2) targeting exon 20 insertions, which penetrates the blood brain barrier, and may inhibit EGFR phosphorylation and downstream signaling, potentially resulting in anti-tumor activity (Cancer Res 2021;81(13_Suppl):Abstract nr 1466).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ORIC-114 ORIC114|ORIC 114 EGFR Inhibitor (Pan) 61 HER2 Inhibitor 41 ORIC-114 is an inhibitor of EGFR and ERBB2 (HER2) targeting exon 20 insertions, which penetrates the blood brain barrier, and may inhibit EGFR phosphorylation and downstream signaling, potentially resulting in anti-tumor activity (Cancer Res 2021;81(13_Suppl):Abstract nr 1466).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05315700 Phase Ib/II Carboplatin + ORIC-114 + Pemetrexed Disodium ORIC-114 Ph 1/2 Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration Recruiting USA | CAN | AUS 1


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