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Therapy Name TPX-4589
Synonyms
Therapy Description

TPX-4589 (LM-302) is an antibody-drug conjugate (ADC) comprising a claudin 18.2 (CLDN18.2) targeted antibody linked to monomethyl auristatin E (MMAE), which potentially inhibits proliferation of CLDN18.2-expressing tumor cells and tumor growth (Eur J Cancer 2022 Vol 174, Supp 1:S41-S42).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
TPX-4589 LM 302|LM302|LM-302|TPX 4589|TPX4589 CLDN18.2 Antibody 18 TPX-4589 (LM-302) is an antibody-drug conjugate (ADC) comprising a claudin 18.2 (CLDN18.2) targeted antibody linked to monomethyl auristatin E (MMAE), which potentially inhibits proliferation of CLDN18.2-expressing tumor cells and tumor growth (Eur J Cancer 2022 Vol 174, Supp 1:S41-S42).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05188664 Phase Ib/II Toripalimab-tpzi + TPX-4589 TPX-4589 Study of LaNova Medicines(LM)-302 in Combination With Toripalimab in Patients With Advanced Solid Tumors Terminated AUS 0
NCT05001516 Phase Ib/II TPX-4589 Study of Turning Point Therapeutics LM-302 in Patients With Advance Solid Tumors Completed USA 0


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