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Therapy Name | RYZ101 |
Synonyms | |
Therapy Description |
RYZ101 is a radioconjugate comprising a somatostatin analog linked to Actinium-225, which delivers radiation to tumor cells expressing SSTRs with a high affinity for SSTR2, potentially inhibiting tumor growth (PMID: 37616528). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
RYZ101 | RYZ-101|RYZ 101|225Ac-DOTATATE RYZ101 | RYZ101 is a radioconjugate comprising a somatostatin analog linked to Actinium-225, which delivers radiation to tumor cells expressing SSTRs with a high affinity for SSTR2, potentially inhibiting tumor growth (PMID: 37616528). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT06411301 | Phase I | RYZ101 | A Phase I Study to Assess the Tolerability of 225Ac-DOTATATE in Patients With Refractory and Relapsing Multiple Myeloma Expressing Somatostatin Receptors (AcTRESS) | Not yet recruiting | BEL | 0 |
NCT05477576 | Phase Ib/II | Everolimus Lanreotide acetate RYZ101 Sunitinib Octreotide acetate | Study of RYZ101 Compared With SOC in Pts w Inoperable SSTR+ Well-differentiated GEP-NET That Has Progressed Following 177Lu-SSA Therapy (ACTION-1) | Active, not recruiting | USA | NLD | FRA | ESP | CAN | BEL | 1 |