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Mithracin (plicamycin) is an antineoplastic antibiotic, which binds to DNA and prevents cells from making RNA and proteins (NCI Drug Dictionary).
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Plicamycin||Mithracin||Mithramycin||Antibiotic Antineoplastic 1||Mithracin (plicamycin) is an antineoplastic antibiotic, which binds to DNA and prevents cells from making RNA and proteins (PMID: 31644044).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||pancreatic cancer||not applicable||Plicamycin||Preclinical - Cell line xenograft||Actionable||In a preclinical study, Mithracin (plicamycin) inhibited tumor growth in several human pancreatic cancer cell line xenograft models (PMID: 17973266).||17973266|
|Unknown unknown||oral squamous cell carcinoma||not applicable||Plicamycin||Preclinical - Cell line xenograft||Actionable||In a preclinical study, Mithracin (plicamycin) inhibited cell growth and induced apoptosis in human oral squamous cell carcinoma cell lines in culture, and inhibited tumor growth and induced apoptosis in a human oral squamous cell carcinoma cell line xenograft model (PMID: 23019217).||23019217|
|Unknown unknown||malignant glioma||not applicable||Plicamycin||Preclinical - Cell culture||Actionable||In a preclinical study, treatment with Mithracin (plicamycin) induced cell death and inhibited migration of glioma cell lines in culture (PMID: 20556479).||20556479|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT01610570||Phase Ib/II||Plicamycin||Mithramycin for Children and Adults With Solid Tumors or Ewing Sarcoma||Terminated|