Therapy Detail

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Therapy Name DSP-5336
Synonyms
Therapy Description

DSP-5336 binds to Menin (MEN1) and inhibits its interaction with MLL (KMT2A), potentially leading to decreased growth of tumor cells harboring MLL (KMT2A) rearrangements or NPM1 mutations (Blood (2021) 138 (Supplement 1): 3339).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
DSP-5336 DSP 5336|DSP5336 MEN1-KMT2A Inhibitor 6 DSP-5336 binds to Menin (MEN1) and inhibits its interaction with MLL (KMT2A), potentially leading to decreased growth of tumor cells harboring MLL (KMT2A) rearrangements or NPM1 mutations (Blood (2021) 138 (Supplement 1): 3339).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KMT2A - AFF1 leukemia predicted - sensitive DSP-5336 Preclinical - Pdx & cell culture Actionable In a preclinical study, DSP-5336 treatment inhibited growth of a leukemia cell line harboring KMT2A-AFF1 (reported as MLL-AF4) in culture, led to antitumor activity in a cell line xenograft model, and resulted in remission and improved survival in a patient-derived xenograft (PDX) model (Blood (2021) 138 (Supplement 1): 3339). detail...
KMT2A - MLLT10 acute myeloid leukemia predicted - sensitive DSP-5336 Preclinical Actionable In a preclinical study, DSP-5336 treatment led to improved survival in a syngeneic mouse model of acute myeloid leukemia harboring KMT2A-MLLT10 (reported as MLL-AF10) (Blood (2021) 138 (Supplement 1): 3339). detail...
KMT2A - MLLT1 acute myeloid leukemia predicted - sensitive DSP-5336 Preclinical Actionable In a preclinical study, DSP-5336 treatment led to improved survival in a syngeneic mouse model of acute myeloid leukemia harboring KMT2A-MLLT1 (reported as MLL-ENL) (Blood (2021) 138 (Supplement 1): 3339). detail...
KMT2A - AFDN acute myeloid leukemia predicted - sensitive DSP-5336 Preclinical - Patient cell culture Actionable In a preclinical study, DSP-5336 treatment inhibited blast colony formation in patient-derived acute myeloid leukemia cells harboring KMT2A-AFDN (reported as MLL-AF6) in culture (Blood (2021) 138 (Supplement 1): 3339). detail...

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04988555 Phase Ib/II DSP-5336 A Study of DSP-5336 in Relapsed/Refractory AML/ ALL With or Without MLL Rearrangement or NPM1 Mutation Recruiting USA 1


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