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Therapy Name CLN-049
Synonyms
Therapy Description

CLN-049 is a bispecific antibody that targets FLT3 and CD3, potentially inducing activation of CD4- and CD8-positive T cells and inhibiting tumor growth (Cancer Res 2022;82(12_Suppl):Abstract nr 2078).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
CLN-049 CLN049|CLN 049 CD3 Antibody 96 FLT3 Antibody 5 CLN-049 is a bispecific antibody that targets FLT3 and CD3, potentially inducing activation of CD4- and CD8-positive T cells and inhibiting tumor growth (Cancer Res 2022;82(12_Suppl):Abstract nr 2078).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 positive acute myeloid leukemia predicted - sensitive CLN-049 Preclinical - Cell line xenograft Actionable In a preclinical study, CLN-049 decreased growth and increased survival in a cell line xenograft model of FLT3-positive acute myeloid leukemia (Cancer Res 2022;82(12_Suppl):Abstract nr 2078). detail...

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05143996 Phase I CLN-049 CLN-049 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML) Recruiting USA 0


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