Therapy Detail
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| Therapy Name | CCT128930 |
| Synonyms | |
| Therapy Description |
CCT128930 is an ATP-competitive inhibitor of AKT2 with a lesser affinity for PKA and RPS6KB2. CCT128930 has antitumor activity in cells with activated PI3K-AKT-mTOR pathway (PMID: 21191045, PMID: 31608140). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| CCT128930 | CCT-128930 | Akt2 Inhibitor 2 | CCT128930 is an ATP-competitive inhibitor of AKT2 with a lesser affinity for PKA and RPS6KB2. CCT128930 has antitumor activity in cells with activated PI3K-AKT-mTOR pathway (PMID: 21191045, PMID: 31608140). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PIK3CA mutant | Her2-receptor positive breast cancer | sensitive | CCT128930 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, CCT128930 induced growth arrest and inhibited tumor growth in a xenograft model of a ERBB2 (HER2)-positive human breast cancer cell line harboring a PIK3CA mutation (PMID: 21191045). | 21191045 |
| PTEN loss | glioblastoma | sensitive | CCT128930 | Preclinical - Cell line xenograft | Actionable | In preclinical studies, CCT128930 prevented tumor growth in a PTEN-null human glioblastoma cell line xenograft model (PMID: 21191045). | 21191045 |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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