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Drug Name Trade Name Synonyms Drug Classes Drug Description
H1299 cell lysate vaccine H1299 cell lysate vaccine comprises cell lysate obtained from the lung tumor cell line H1299, which potentially induces immunity against cancer-testis antigens (CTAs) and increases anti-tumor immune response (PMID: 34430349).
Montanide ISA 51
Nogapendekin alfa inbakicept Anktiva N-803|N803|N 803|nogapendekin alfa|ALT803|ALT 803|ALT-803 Anktiva (nogapendekin alfa inbakicept) is a fusion protein comprising a mutant version of IL-15 with increased activity and IL-15Ra fused to the Fc region of IgG1, which activates CD8+ T-cells and promotes effector activity, potentially resulting in increased antitumor immune response (PMID: 24404427, PMID: 31338557). Anktiva (nogapendekin alfa inbakicept) in combination with BCG is FDA approved for use in patients with BCG-unresponsive non-muscle invasive bladder cancer with carcinoma in situ with or without papillary tumors (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05642195 Phase Ib/II H1299 cell lysate vaccine + Montanide ISA 51 + Nogapendekin alfa inbakicept H1299 cell lysate vaccine + Montanide ISA 51 Evaluation of a Cancer Lysate Vaccine and Montanide (Registered Trademark) ISA-51 VG With or Without the IL-15 Super-Agonist N-803 as Adjuvant Therapy for PD-L1 Negative Non-Small Cell Lung Cancer Recruiting USA 0


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