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Therapy Name ABBV-101
Synonyms
Therapy Description

ABBV-101 is a selective BTK degrader, with activity against mutant BTK, which potentially inhibits tumor growth (Cancer Res (2024) 84 (6_Supplement): 605).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ABBV-101 ABBV 101|ABBV101 BTK inhibitor 36 ABBV-101 is a selective BTK degrader, with activity against mutant BTK, which potentially inhibits tumor growth (Cancer Res (2024) 84 (6_Supplement): 605).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BTK C481S diffuse large B-cell lymphoma predicted - sensitive ABBV-101 Preclinical - Cell line xenograft Actionable In a preclinical study, ABBV-101 treatment resulted in tumor regression in a cell line xenograft model of diffuse large B-cell lymphoma harboring BTK C481S (Cancer Res (2024) 84 (6_Supplement): 605). detail...
BTK C481S chronic lymphocytic leukemia predicted - sensitive ABBV-101 Preclinical Actionable In a preclinical study, ABBV-101 treatment resulted in reduced tumor burden in the spleen and lymph nodes and decreased leukemic burden in the blood compartment of a mouse model of chronic lymphocytic leukemia harboring BTK C481S (Cancer Res (2024) 84 (6_Supplement): 605). detail...

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05753501 Phase I ABBV-101 Study to Evaluate Adverse Events, Change in Disease Activity, and How Oral ABBV-101 Moves Through the Body in Adult Participants With B-Cell Malignancies Recruiting USA | GBR | ESP | DEU 2


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