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|Therapy Name||Obinutuzumab + ST-067|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Obinutuzumab||Gazyva||R7159|afutuzumab|GA101|GA-101|RO 5072759||CD20 Antibody 21||Gazyva (obinutuzumab) is a glycoengineered anti-CD20 antibody that binds to CD20 on B-cells, resulting in increased antibody-dependent cellular cytotoxicity and induction of apoptosis, and potentially leading to decreased growth of B-cell tumors (PMID: 20194898, PMID: 21220500). Gazyva (obinutuzumab) is FDA approved in combination with Ambochlorin (chlorambucil) for chronic lymphocytic leukemia and in combination with Treanda (bendamustine) or chemotherapy for follicular lymphoma (FDA.gov).|
|ST-067||ST067|ST 067||ST-067 is a modified version of IL-18, which activates the IL-18 receptor, potentially leading to enhanced antitumor immune response (NCI Thesaurus).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04787042||Phase Ib/II||Pembrolizumab + ST-067 ST-067 Obinutuzumab + ST-067||Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067||Recruiting||USA||0|