Therapy Detail

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Therapy Name UNC1999
Synonyms
Therapy Description

UNC1999 inhibits EZH1 and EZH2, resulting in decreased H3K27 tri-methylation, and potentially leading to decreased tumor cell proliferation (PMID: 23614352, PMID: 24183969).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
UNC1999 EZH1 inhibitor 3 EZH2 inhibitor 18 UNC1999 inhibits EZH1 and EZH2, resulting in decreased H3K27 tri-methylation, and potentially leading to decreased tumor cell proliferation (PMID: 23614352, PMID: 24183969).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ARID1A mutant ovarian cancer sensitive UNC1999 Preclinical - Cell culture Actionable In a preclinical study, UNC1999 inhibited growth of ovarian cancer cell lines harboring ARID1A mutations in culture (PMID: 25686104). 25686104
ATRX fusion neuroblastoma predicted - sensitive UNC1999 Preclinical - Cell line xenograft Actionable In a preclinical study, treatment with UNC1999 resulted in reduced proliferation and increased apoptosis of neuroblastoma cell lines harboring in-frame ATRX fusions in culture, and decreased tumor growth in a neuroblastoma cell line xenograft model harboring an ATRX fusion (PMID: 31631027). 31631027
EZH2 Y641N diffuse large B-cell lymphoma sensitive UNC1999 Preclinical Actionable In a preclinical study, UNC1999 treatment reduced H3K27me3 levels, decreased proliferation, and increased cell death in diffuse large B-cell lymphoma cells harboring an EZH2 Y641N mutation in cell culture (PMID: 23614352). 23614352

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status


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