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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Deguelin||PI3K Inhibitor (Pan) 37||Deguelin is a plant-derived rotenoid that is a pan-PI3K inhibitor, which may enhance chemosensitivity (PMID: 15916691, PMID: 12591985).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|NPM1 exon12||acute myeloid leukemia||sensitive||Deguelin||Preclinical||Actionable||In preclinical studies, deguelin treatment of an AML cell line harboring NPM1 exon12 mutation resulted in reduced levels of mutant Npm1 protein and induced differentiation of the cells (PMID: 25242579, PMID: 25348016).||25242579 25348016|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|