Therapy Detail

Therapy Name Aldesleukin + GD2Bi-a ATC + Sargramostim
Therapy Description


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Drug Name Trade Name Synonyms Drug Classes Drug Description
Aldesleukin Proleukin IL-2
GD2Bi-a ATC anti-CD3 x hu3F8 bispecific antibody-armed ATC GD2Bi-a ATC are autologous T-cells that have been “armed” with bispecific antibodies that target both GD2 and CD3, resulting in cytotoxicity of GD2-expressing tumor cells by cross-linking activated T-cells to GD2-positive tumor cells, and may also enhance CTL-mediated response tumor cells (NCI Drug Dictionary).
Sargramostim Leukine GM-CSF|Prokine
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status
NCT02173093 Phase Ib/II Aldesleukin + GD2Bi-a ATC + Sargramostim Activated T Cells Armed With GD2 Bispecific Antibody in Children and Young Adults With Neuroblastoma and Osteosarcoma Recruiting