Therapy Detail

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Therapy Name Oprozomib
Synonyms
Therapy Description

Oprozomib (ONX 0912) is a proteasome inhibitor that inhibits CT-L proteosome activity, leading to induction of autophagy and apoptosis in tumor cells (PMID: 22929803).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Oprozomib ONX 0912 Oprozomib (ONX 0912) is a proteasome inhibitor that inhibits CT-L proteosome activity, leading to induction of autophagy and apoptosis in tumor cells (PMID: 22929803).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor no benefit Oprozomib Phase I Actionable In a Phase I trial, Oprozomib (ONX 0912) demonstrated clinically relevant toxicity and minimal efficacy, with stable disease as best response in patients with advanced solid tumors (PMID: 26924128). 26924128
Unknown unknown multiple myeloma not applicable Oprozomib Phase II Actionable In a Phase II trial, Oprozomib (ONX 0912) treatment resulted in an objective response rate of 41.0%, 28.1%, and 25.0% in the 2/7, 240/300-mg/day; 5/14, 150/180-mg/day; and 5/14, 240-mg/day cohorts of patients with multiple myeloma (n=95) (PMID: 31142508; NCT01416428). 31142508
Unknown unknown Waldenstroem's macroglobulinemia not applicable Oprozomib Phase II Actionable In a Phase II trial, Oprozomib (ONX 0912) treatment resulted in an objective response rate of 71.4% and 47.1% in the 2/7 and 5/14 cohorts of patients with Waldenstroem's macroglobulinemia (n=31) (PMID: 31142508; NCT01416428). 31142508

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  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Clinical Trial Phase Therapies Title Recruitment Status
NCT02227914 Phase Ib/II Oprozomib Sorafenib Phase 1b/2 Study of Oprozomib in Combination With Sorafenib in Subjects With Advanced Hepatocellular Carcinoma Withdrawn


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